Simkania negevensis and acute cellular rejection in lung transplant recipients.
Simkania negevensis and acute cellular rejection in lung transplant recipients.
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Simkania negevensis 和肺移植受者的急性细胞排斥。
DOI：
10.1111/ctr.12571
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发表时间：
2015
影响因子：
2.1
通讯作者：
Husain,Shahid
中科院分区：
文献类型：
--
作者：
Jamal,AlainnaJ;Resende,MariangelaR;Prochnow,Taisa;McGilvray,Ian;Pilewski,JosephM;Crespo,MariaM;Singer,LianneG;McCurry,KennethR;Kolls,JayK;Keshavjee,Shaf;Liles,WConrad;Husain,Shahid
Simkania negevensis感染已被假设在肺移植排斥反应中发挥作用。2007年7月至2010年1月在加拿大多伦多和美国匹兹堡对78例肺移植受者（LTR）进行前瞻性队列研究，分析其感染率及其与急性细胞排斥反应（ACR）的关系。采用考克斯比例风险模型和广义线性和潜在混合模型研究了S.negevensis与ACR之间的关系。6个月时，阴性葡萄球菌PCR阳性与PCR阴性LTR中至ACR时间的累积发生率估计值分别为52.7%与31.1%，1年时分别为68.9%与44.6%。尽管无统计学显著性，但在所有统计模型中，ACR阴性阴性LTR与PCR阳性LTR相比，存在ACR阴性LTR风险更高的趋势。
Simkania negevensisinfection has been hypothesized to play a role in lung transplant rejection. The incidence ofS. negevensisinfection and its association with acute cellular rejection (ACR) were determined in a prospective cohort study of 78 lung transplant recipients (LTRs) in Toronto, Canada, and Pittsburgh, USA, from July 2007 to January 2010.Simkania negevensistesting was detected by quantitative polymerase chain reaction (PCR) on bronchoalveolar lavage fluid. The relationship betweenS. negevensisand ACR was examined using Cox proportional hazards models and generalized linear and latent mixed models. Cumulative incidence estimates for time‐to‐ACR inS. negevensisPCR‐positive vs. PCR‐negative LTRs were 52.7% vs. 31.1% at six months and 68.9% vs. 44.6% at one yr, respectively. Although not statistically significant, there was a trend toward a higher risk of ACR amongS. negevensisPCR‐positive vs. PCR‐negative LTRs in all statistical models.