Serum osteocalcin level as an indicator of low-grade albuminuria in Chinese men free of kidney disease
Serum osteocalcin level as an indicator of low-grade albuminuria in Chinese men free of kidney disease
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血清骨钙素水平作为中国无肾病男性低度蛋白尿的指标
DOI：
10.1080/03007995.2018.1541791
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发表时间：
2019
影响因子：
2.3
通讯作者：
Bao Yuqian
中科院分区：
文献类型：
--
作者：
Xu Yiting;Ma Xiaojing;Shen Yun;Xiong Qin;Zhang Xueli;Bao Yuqian
目的：低级别蛋白尿（LGA）的出现提示血管功能障碍的病理生理机制已经启动。明确的证据支持骨钙素在能量代谢中的作用和心血管病变的发病率很高。观察性社区研究旨在研究骨钙素与LGA的关系，这可能为骨钙素在心血管疾病中的潜在参与提供新的见解。方法：来自上海的1951名成年人[58.37（53.34-63.13）岁，41.3%男性]被纳入。LGA定义为尿白蛋白与肌酐比值（UACR）< 30 mg/g。血清骨钙素测定使用电化学发光immunoassociation.Results：血清骨钙素水平在男性下降，增加UACR调整后的潜在协变量（p= 0.045），但调整后的关联消失在女性（p= 0.258）。线性回归分析显示，骨钙素是男性UACR的负变量（标准化β=-0.074，p = 0.030），在非高血糖、非高血压男性中尤其突出，即使不考虑估计肾小球滤过率（eGFR）（60 ≤ eGFR <90 mL/min/1.73 m2，标准化β=− 0.422，p = 0.004; ≥ 90 mL/min/1.73 m2，标准化β= − 0.167，p = 0.037）。结论：在控制混杂因素后，血清骨钙素水平与男性LGA独立相关，提示骨钙素与动脉粥样硬化和血管功能障碍密切相关。
Objective:The presence of low-grade albuminuria (LGA) suggested that the pathophysiology of vascular dysfunction has been initiated. Clear evidence supports a role for osteocalcin in energy metabolism and a great incidence of pathological cardiovascular changes. The observational community-based study aims to examine the association of osteocalcin with LGA, which may provide new insight into potential involvement of osteocalcin in cardiovascular diseases.Methods:A total of 1951 adults [58.37 (53.34–63.13) years, 41.3% men] from Shanghai were enrolled. LGA was defined as a urinary albumin-to-creatinine ratio (UACR) < 30 mg/g. Serum osteocalcin was measured using an electrochemiluminescence immunoassay.Results:Serum osteocalcin level in men decreased with increasing UACR after adjusting for potential covariates (p= 0.045); however, the adjusted association disappeared in women (p= 0.258). Linear regression analysis showed that osteocalcin was a negative variable of UACR in men (standardizedβ= −0.074,p= 0.030), particularly prominent in non-hyperglycemic, non-hypertensive men, even regardless of estimated glomerular filtration rate (eGFR) (60 ≤ eGFR <90 mL/min/1.73 m2, standardizedβ=−0.422,p= 0.004; ≥ 90 mL/min/1.73 m2, standardizedβ= −0.167,p= 0.037).Conclusion:After controlling for confounders, serum osteocalcin level was independently associated with LGA in men, which suggested that osteocalcin was closely related with atherosclerosis and vascular dysfunction.