Neural and hormonal regulation of pancreatic secretion.
Neural and hormonal regulation of pancreatic secretion.
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DOI：
10.1097/mog.0b013e32832e9c41
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发表时间：
2009-09
影响因子：
2.5
通讯作者：
Liddle RA
中科院分区：
文献类型：
--
作者：
Chandra R;Liddle RA
胰腺的生物学非常复杂，涉及内分泌和外分泌功能，这些功能受到一系列神经和激素过程的综合调控。本文综述了胰腺内分泌和外分泌调节的最新进展。新的数据表明，胆囊收缩素可以刺激位于迷走神经背侧运动核的神经元。解决一个有争议的话题，最近的证据表明，CCK对人类腺泡细胞的直接分泌作用。一个新兴的概念是，一些激素和肽，如褪黑激素，生长激素释放肽，肥胖抑制素和瘦素在胰腺中通过调节分泌和维持代谢稳态来执行双重功能。本文还讨论了几种食欲调节神经肽如ghrelin、orexin A、NPY对胰腺分泌的调节作用。最近的数据突出表明，激素作用的机制可能是不同的物种之间可能是由于在进化过程中的信号通路的分歧。许多激素对胰腺分泌功能的调节表明，有多种可能是冗余的信号控制着这个重要器官。了解这些不同的途径是必不可少的治疗胰腺炎，糖尿病和肥胖症。
The biology of the pancreas is exquisitely complex and involves both endocrine and exocrine functions that are regulated by an integrated array of neural and hormonal processes. This review discusses recent developments in the regulation of both endocrine and exocrine secretion from the pancreas. New data suggest that cholecystokinin can stimulate neurons located in the dorsal motor nucleus of the vagus. Addressing a controversial topic, recent evidence suggests a direct secretory action of CCK on human acinar cells. An emerging concept is that some hormones and peptides such as melatonin, ghrelin, obestatin and leptin perform dual functions in the pancreas by regulating secretion and maintaining metabolic homeostasis. The regulation of pancreatic secretion by several appetite-controlling neuropeptides such as ghrelin, orexin A, NPY, is also discussed. Recent data highlight findings that mechanisms of hormone action may be different between species possibly due to a divergence in signaling pathways during evolution. The regulation of the secretory function of the pancreas by numerous hormones suggests that there are multiple and perhaps redundant signals governing the control of this important organ. Understanding these diverse pathways is essential to the treatment of pancreatitis, diabetes and obesity.