The CD44 protein family
The CD44 protein family
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DOI：
10.1016/s1357-2725(97)00152-0
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发表时间：
1998-03-01
影响因子：
4
通讯作者：
Herrlich, P
中科院分区：
文献类型：
--
作者：
Ponta, H;Wainwright, D;Herrlich, P
CD44描述了一组共享N-端和C-端序列的I型跨膜蛋白。这些分子在中央细胞外域的不同之处在于使用了由10个可能完全不存在或包含在不同组合中的变异外显子编码的序列，以及通过添加糖胺聚糖和碳水化合物部分的细胞类型而不同。在成体的角质形成细胞、树突状细胞和活化的淋巴细胞等正常组织以及胚胎中具有形态发生活性的上皮细胞如顶端外胚脊(AER)上均可观察到不同蛋白的表达。AER上表达的某些CD44蛋白可以作为低亲和力的成纤维细胞生长因子受体，对上皮-间充质细胞的通讯至关重要。CD44不同的蛋白也参与了肿瘤的生长和转移，我们推测CD44介导的生长因子提呈也可能在转移的形成中起决定性作用。旨在阻断CD44提供生长因子的分子策略可能有助于转移性癌症的治疗。(C)1998爱思唯尔科学有限公司。保留所有权利。
The designation CD44 describes a group of type I transmembrane proteins which share N-terminal and C-terminal sequences. These molecules differ in the central extracellular domain by the use of sequences encoded by ten variant exons which may be completely absent or included in various combinations and by cell type specific addition of glycosaminoglycan and carbohydrate moieties. Expression of variant proteins is observed in normal tissues such as on keratinocytes, dendritic cells and activated lymphocytes in the adult organism and on morphogenetically active epithelium such as the apical ectodermal ridge (AER) in the embryo. Certain CD44 proteins expressed on the AER can act as low affinity fibroblast growth factor receptors and are vital for epithelial-mesenchymal cell communication. CD44 variant proteins have also been implicated; in tumour growth and metastasis and we speculate that CD44 mediated growth factor presentation may also be decisive in metastasis formation. Molecular strategies designed to block growth factor presentation by CD44 may aid in the therapy of metastatic cancer. (C) 1998 Elsevier Science Ltd. All rights reserved.