Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission.
Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission.
复制标题
DOI：
10.1038/s41467-022-28371-z
复制
发表时间：
2022-02-23
影响因子：
16.6
通讯作者：
Harrison EM
中科院分区：
文献类型：
--
作者：
Aggarwal D;Page AJ;Schaefer U;Savva GM;Myers R;Volz E;Ellaby N;Platt S;Groves N;Gallagher E;Tumelty NM;Le Viet T;Hughes GJ;Chen C;Turner C;Logan S;Harrison A;COVID-19 Genomics UK (COG-UK) Consortium;Peacock SJ;Chand M;Harrison EM
减少国际旅行引起的SARS-CoV-2传播是一个优先事项。我们评估了2020年夏季旅客返回英国时被要求隔离14天的有效性。我们确定了4，207例与旅行有关的SARS-CoV-2病例及其接触者，并确定了827个相关的SARS-CoV-2基因组。总体而言，隔离与较低的接触率有关，隔离的影响在16-20岁年龄组中最大。186个SARS-CoV-2基因组足够独特，可以识别与旅行相关的簇。与没有检疫要求的国家相比，从有检疫要求的国家返回的指示病例中观察到的基因组相关病例较少。这种差异的原因是，这些病例中每个已确定基因组的输入事件较少，而每个病例的后续接触较少。总的来说，我们的研究表明，14天的隔离期减少了但并没有完全消除输入性病例的传播，主要是通过劝阻前往有隔离要求的国家旅行。国际旅行后隔离已被广泛实施，以减轻SARS-CoV-2的传播，但这些政策的影响尚不清楚。在这里，作者使用相关的基因组和接触者追踪数据来评估2020年夏天返回英国的14天隔离的影响。
Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16–20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement. Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020.
登录
查看更多内容
影响因子：
2.7
作者：
Garces-Ayala, Fabiola;Araiza-Rodriguez, Adnan;Ramirez-Gonzalez, Jose Ernesto
通讯作者：
Ramirez-Gonzalez, Jose Ernesto
影响因子：
4.9
作者：
Gómez-Carballa A;Bello X;Pardo-Seco J;Pérez Del Molino ML;Martinón-Torres F;Salas A
通讯作者：
Salas A
影响因子：
3.9
作者：
Connor TR;Loman NJ;Thompson S;Smith A;Southgate J;Poplawski R;Bull MJ;Richardson E;Ismail M;Thompson SE;Kitchen C;Guest M;Bakke M;Sheppard SK;Pallen MJ
通讯作者：
Pallen MJ
影响因子：
14.9
作者：
Cochrane G;Karsch-Mizrachi I;Takagi T;International Nucleotide Sequence Database Collaboration
通讯作者：
International Nucleotide Sequence Database Collaboration
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin