Recommendations from a multi-study evaluation of proposed criteria for Staging Reproductive Aging
Recommendations from a multi-study evaluation of proposed criteria for Staging Reproductive Aging
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DOI：
10.1080/13697130701258838
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发表时间：
2007-04-01
期刊：
影响因子：
2.8
通讯作者：
Sowers, M.-F.
中科院分区：
文献类型：
--
作者：
Harlow, S. D.;Crawford, S.;Sowers, M.-F.
2001年，生殖衰老阶段研讨会（STRAW）提出了定义绝经早期和晚期过渡阶段的出血和内分泌标准。根据专家共识，STRAW 建议闭经间隔时间比常用的 90 天闭经标准更短，用于晚过渡期；对于早过渡期，月经周期长度的变化 > 7 天。 ReSTAGE 合作使用来自四个队列（TREMIN、墨尔本妇女中年健康项目、西雅图中年妇女健康研究和全国妇女健康研究）的前瞻性月经日历数据来定量评估 STRAW 的建议。该实证评估支持 STRAW 的建议，即 (1) 使用 >= 60 天的闭经来定义晚期绝经过渡，(2) 早期过渡与连续周期长度持续 7 天或以上的差异一致。血清卵泡刺激素 (FSH) 值 >= 40 IU/I 是过渡的独立标记，当与出血标记一起出现时，可以增加对末次月经的预测。这样的 FSH 标准可以纳入 STRAW 范式中，以方便预测末次月经的临近时间。
In 2001, the Stages of Reproductive Aging Workshop (STRAW) proposed bleeding and endocrine criteria for defining the early and late menopausal transition stages. Based on expert consensus, STRAW recommended a shorter interval of amenorrhea than the commonly used 90-day amenorrhea criteria for late transition and a > 7-day change in cycle length for early transition. The ReSTAGE collaboration used prospective menstrual calendar data from four cohorts (TREMIN, Melbourne Women's Midlife Health Project, Seattle Midlife Women's Health Study, and Study of Women's Health Across the Nation) to quantitatively evaluate STRAW's recommendations. This empirical assessment supported the STRAW recommendations that (1) >= 60 days of amenorrhea be used to define the late menopausal transition and (2) that early transition is consistent with a persistent 7 or more day difference in length of consecutive cycles. Serum follicle stimulating hormone (FSH) values >= 40 IU/I was an independent marker of the transition and, when occurring together with a bleeding marker, increased prediction of final menstrual period. Such a FSH criterion could be incorporated into the STRAW paradigm to facilitate prediction of proximity of the final menstrual period.