Depression and pesticide exposures in female spouses of licensed pesticide applicators in the agricultural health study cohort
Depression and pesticide exposures in female spouses of licensed pesticide applicators in the agricultural health study cohort
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DOI：
10.1097/01.jom.0000235938.70212.dd
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发表时间：
2006-10-01
影响因子：
3.2
通讯作者：
Kamel, Freya
中科院分区：
文献类型：
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作者：
Beseler, Cheryl;Stallones, Lorann;Kamel, Freya
目的：本巢式病例对照研究评估女性抑郁症与农药暴露之间的关系。方法：研究人群包括1993 - 1997年农业健康研究中登记的29,074名私人农药施药者的女性配偶。病例是那些被医生诊断患有抑郁症需要药物治疗的女性。终生农药使用分为从未混合/施用农药、低暴露（最多225天）、高暴露（最多225天）和诊断为农药中毒的历史。结果：在调整州、年龄、种族、非农工作、饮酒、吸烟、就诊和溶剂暴露等因素后，抑郁症与农药中毒史显著相关（优势比[OR] = 3.26； 95%可信区间[G] = 1.72-619），但与低（OR = 1.09; CI = 0.91-1.31）或高（OR = 1.09; 95% CI = 0.91-1.31）累积农药暴露无关。结论：农药中毒可能增加抑郁风险。
Objective: This nested case-control study evaluated the association between depression and pesticide exposure among women. Methods: The study population included 29,074,female spouses of private pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Cases were women who had physician-diagnosed depression requiring medication. Lifetime pesticide use was categorized as never mixed/applied pesticides, low exposure (up to 225 days), high exposure (> 225 days), and a history of diagnosed pesticide poisoning. Results: After adjustment for state, age, race, off-farm work alcohol, cigarette smoking, physician visits, and solvent exposure, depression was significantly associated with a history of pesticide poisoning (odds ratio [OR] = 3.26; 95% confidence interval [G] = 1.72-619) but not low (OR = 1.09; CI = 0.91-1.31) or high (OR = 1.09; 95% CI = 0.91-1.31) cumulative pesticide exposure. Conclusion: Pesticide poisoning may contribute to risk of depression.