HETEROCHRONIC MUTANTS OF THE NEMATODE CAENORHABDITIS-ELEGANS
HETEROCHRONIC MUTANTS OF THE NEMATODE CAENORHABDITIS-ELEGANS
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DOI：
10.1126/science.6494891
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
HORVITZ, HR
中科院分区：
文献类型：
--
作者：
AMBROS, V;HORVITZ, HR
秀丽线虫基因lin-14、lin-28和lin-29的突变会导致异质性发育缺陷：一些组织中特定发育事件的发生时间相对于其他组织中发生事件的时间发生变化。这些缺陷是由特定细胞命运的时间变化造成的，即某些细胞表达其他发育阶段产生的细胞正常表达的命运。可以突变导致异时性的基因的鉴定和特征支持了异时性是系统发育变化的机制的观点，并提出了异时性变异的细胞和遗传学基础。
Mutations in theCaenorhabditis elegansgeneslin-14,lin-28, andlin-29cause heterochronic developmental defects: the timing of specific developmental events in several tissues is altered relative to the timing of events in other tissues. These defects result from temporal transformations in the fates of specific cells, that is, certain cells express fates normally expressed by cells generated at other developmental stages. The identification and characterization of genes that can be mutated to cause heterochrony support the proposal that heterochrony is a mechanism for phylogenetic change and suggest cellular and genetic bases for heterochronic variation.