Anodal transcranial direct current stimulation enhances positive changes in movement functions, visual attention and depression of patients with chronic ischemic stroke: A clinical trial
Anodal transcranial direct current stimulation enhances positive changes in movement functions, visual attention and depression of patients with chronic ischemic stroke: A clinical trial
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DOI：
10.15419/bmrat.v5i11.503
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发表时间：
2018-01-01
影响因子：
0.9
通讯作者：
Khaksarian, Mojtaba
中科院分区：
文献类型：
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作者：
Hosseinzadeh, Seyed Ahmad;Mazhari, Shahrzad;Khaksarian, Mojtaba
导言：中风是当今社会最严重、最令人衰弱的疾病之一。中风幸存者可能会遭受几种神经损伤。它们通常显示出大脑区域神经功能的病理变化。经颅直流电刺激(TDC)可用于改善大脑兴奋性，近年来已被应用于神经心理和神经疾病的治疗。本研究的目的是使用阳极和阴极TDC来评估慢性缺血性中风患者运动和认知功能的变化。方法：将100例慢性缺血性卒中患者随机分为4组(对照组、假手术组、阳极组和阴极组，每组25例)。患者接受常规治疗，并接受相同的tdcs方案(一个月内每周3次，每次30分钟)。在治疗前、治疗后1个月和3个月分别采用NIHSS量表、连线测验和Beck测验对患者的运动和认知功能进行评估。所有数据用SPSS软件(Version 18)进行双向重复测量方差分析。结果：治疗前后比较，差异有统计学意义(P
Introduction: Stroke is one of the most serious and debilitating diseases in our society. Stroke survivors can suffer several neurological impairments. They typically show pathological changes in neural functions of brain areas. Transcranial direct current stimulation (tDCS) can be applied to modify cerebral excitability and has been recently applied in the treatment of neuropsychological and neurological disorders. The aim of the study herein was to evaluate changes in movement and cognitive functions of chronic ischemic stroke patients using anodic and cathodic tDCS. Method: In this clinical trial, 100 patients with chronic ischemic stroke were divided in 4 groups (control, sham, anodic tDCS, and cathodic tDCS; n=25 per group). The patients underwent routine treatment and received the same tDCS protocol (3 times per week of 30-min sessions during one month). Movement and cognitive functions were evaluated using the NIHSS Scale &Trail Making Test and the Beck Test, before and after 1 and 3 months of tDCS sessions. All data were analyzed by 2-way repeated measures ANOVA using SPSS program (version 18). Results: The results showed that there were significant increases (P