Organophosphine bearing multiple hydrogen-bond donors for asymmetric Michael addition reaction of 1-oxoindane-2-carboxylic acid ester via dual-reagent catalysis
Organophosphine bearing multiple hydrogen-bond donors for asymmetric Michael addition reaction of 1-oxoindane-2-carboxylic acid ester via dual-reagent catalysis
复制标题
带有多个氢键供体的有机膦双试剂催化l-氧茚烷-2-羧酸酯的不对称迈克尔加成反应
DOI：
10.1016/j.cclet.2020.07.026
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发表时间：
2021-03-30
影响因子：
9.1
通讯作者：
Shang, Yongjia
中科院分区：
文献类型：
--
作者：
Hong, Haoran;Wang, Hongyu;Shang, Yongjia
来自二肽双试剂的含有多个氢键的亲核膦在温和的反应条件下催化茚酯和活化烯烃之间的不对称迈克尔加成反应，产率高，并且具有良好至优异的对映选择性。当前高选择性反应的成功应该为其他反应的扩展提供灵感，并为具有手性季碳中心的茚满酮衍生物的合成开辟新的范例。 (C) 2020 中国化学会、中国医学科学院药物研究所。由 Elsevier B.V. 出版。保留所有权利。
Multiple hydrogen bonds containing nucleophilic phosphines derived from dipeptide dual-reagents catalyzed asymmetric Michael addition reactions between indene esters and activated olefins in high yields and good to excellent enantioselectivities under mild reaction conditions. The success of current highly selective reactions should provide inspiration for expansion to other reactions and would open up new paradigms for the synthesis of indanone derivatives bearing chiral quaternary carbon centers. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.