Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity
Jejunal or portal vein infusions of lipids increase hepatic vagal afferent activity
复制标题
空肠或门静脉输注脂质可增加肝迷走神经传入活动
作者：
A. Randich;D. S. Spraggins;J. E. Cox;S. T. Meller;G. R. Kelm
空肠输注亚油酸、玉米油或辛酸显著增加肝迷走神经传入活性，而生理盐水输注则无效。亚油酸和玉米油的响应幅度最大。肝门静脉输注亚油酸、脂素II或辛酸可显著增加肝迷走神经传入活性，而5%白蛋白/磷酸盐缓冲体无效。亚油酸和Liposyn II的反应幅度最大。这些数据表明，空肠或门静脉输注脂质可增加肝迷走神经传入的活性，并可能作为乳糜泻迷走神经传入的补充和/或替代底物，介导空肠输注脂质抑制食物摄入的作用。
Jejunal infusions of linoleic acid, corn oil, or caprylic acid significantly increased hepatic vagal afferent activity, whereas saline infusions were ineffective. The magnitude of response was greatest with either linoleic acid or corn oil. Hepatic portal infusions of linoleic acid, Liposyn II, or caprylic acid significantly increased hepatic vagal afferent activity, whereas 5% albumin/phosphate buffer vehicle was ineffective. The magnitude of response was greatest with either linoleic acid or Liposyn II. These data show that either jejunal or portal infusions of lipids increase activity of hepatic vagal afferents and could potentially serve as a complementary and/or alternative substrate to celiac vagal afferents in mediating the effects of jejunal infusions of lipids in suppressing food intake.