Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis
Internalization of Leishmania mexicana complex amastigotes via the Fc receptor is required to sustain infection in murine cutaneous leishmaniasis
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DOI：
10.1084/jem.191.6.1063
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发表时间：
2000-03-20
影响因子：
15.3
通讯作者：
McMahon-Pratt, D
中科院分区：
文献类型：
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作者：
Kima, PE;Constant, SL;McMahon-Pratt, D
我们在这里表明，维护利什曼原虫感染与墨西哥利什曼原虫复合寄生虫（利什曼原虫亚马逊和利什曼原虫pifanoi）在循环抗体的情况下受损。在这些研究中，我们使用了基因改变为不含循环抗体的小鼠，有和没有功能性B细胞。该实验设计使我们能够排除利什曼原虫发病机制中B细胞抗原呈递的关键作用。此外，我们发现，缺乏Fc受体（Fc γ RI，Fc γ RI和Fc γ RIII）的共同γ链的小鼠同样难以感染这些寄生虫。这些观察结果确立了抗体在与L.墨西哥情结
We show here that maintenance of Leishmania infections with Leishmania mexicana complex parasites (Leishmania amazonensis and Leishmania pifanoi) is impaired in the absence of circulating antibody. In these studies, we used mice genetically altered to contain no circulating antibody, with and without functional B cells. This experimental design allowed us to rule out a critical role for B cell antigen presentation in Leishmania pathogenesis. In addition, we show that mice lacking the common gamma chain of Fc receptors (Fc gamma RI, Fc epsilon RI, and Fc gamma RIII) are similarly refractory to infection with these parasites. These observations establish a critical role for antibody in the pathogenesis associated with infection by members of the L. mexicana complex.