Type 2 Diabetes and Cancer: What Is the Connection?
Type 2 Diabetes and Cancer: What Is the Connection?
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DOI：
10.1002/msj.20167
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发表时间：
2010-03-01
影响因子：
--
通讯作者：
LeRoith, Derek
中科院分区：
文献类型：
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作者：
Cannata, Dara;Fierz, Yvonne;LeRoith, Derek
流行病学研究表明2型糖尿病与癌症之间存在关联。2型糖尿病的特征是胰岛素抵抗和高胰岛素血症。高胰岛素血症可能通过胰岛素对其同源受体和胰岛素样生长因子系统的作用而导致癌症。胰岛素和胰岛素样生长因子对癌症发展和进展的影响已在动物和人类研究中得到证实。2型糖尿病与乳腺癌、结肠癌和胰腺癌呈正相关。2型糖尿病和前列腺癌之间存在反比关系，这可能是由于2型糖尿病男性的睾酮水平较低。用于治疗2型糖尿病的药物可能通过影响血清胰岛素水平直接或间接影响癌细胞。高胰岛素血症可能是癌症的重要危险因素，也是癌症治疗的靶点。Mt Sinai J Med 77：197-213，2010. (C)2010年西奈山医学院
Epidemiological studies have demonstrated an association between type 2 diabetes and cancer. Type 2 diabetes is characterized by insulin resistance and hyperinsulinemia. Hyperinsulinemia may lead to cancer through insulin's effect on its cognate receptor and the insulin-like growth factor system. The effects of insulin and insulin-like growth factor on cancer development and progression have been demonstrated in animal and human studies. Type 2 diabetes has been positively associated with cancers of the breast, colon, and pancreas. An inverse relationship has been observed between type 2 diabetes and prostate cancer, and this may be due to lower testosterone levels in men with type 2 diabetes. Medications used to treat type 2 diabetes may affect cancer cells directly or indirectly by affecting serum insulin levels. Hyperinsulinemia may be an important risk factor for cancer as well as a target for cancer therapy. Mt Sinai J Med 77:197-213, 2010. (C) 2010 Mount Sinai School of Medicine