Epigenetic Dysregulation in Cancer
Epigenetic Dysregulation in Cancer
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DOI：
10.2353/ajpath.2009.081142
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发表时间：
2009-10-01
影响因子：
6
通讯作者：
Hess, Jay L.
中科院分区：
文献类型：
--
作者：
Muntean, Andrew G.;Hess, Jay L.
细胞分化中最大的悖论之一是具有相同DNA序列的细胞如何分化成如此多不同的细胞类型。这一过程的机制涉及DNA甲基化、组蛋白翻译后修饰和核小体重塑等改变所介导的表观遗传调控。越来越清楚的是，由于表观遗传调节器的改变而导致的“表观基因组”的破坏是癌症的一个基本机制。这对分子诊断学和癌症化疗的未来都有重大影响。(Am J Pathol1361；doi：10.2353/ajpath.2009.081142)
One of the great paradoxes in cellular differentiation is how cells with identical DNA sequences differentiate into so many different cell types. The mechanisms underlying this process involve epigenetic regulation mediated by alterations in DNA methylation, histone posttranslational modifications, and nucleosome remodeling. It is becoming increasingly clear that disruption of the "epigenome" as a result of alterations in epigenetic regulators is a fundamental mechanism in cancer. This has major implications for the future of both molecular diagnostics as well as cancer chemotherapy. (Am J Pathol 1361; DOI: 10.2353/ajpath.2009.081142)