Progress of Exosomes in the Diagnosis and Treatment of Pancreatic Cancer.
Progress of Exosomes in the Diagnosis and Treatment of Pancreatic Cancer.
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DOI：
10.1089/gtmb.2018.0235
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发表时间：
2019-03
影响因子：
1.4
通讯作者：
Hongpei Wu;Xiaojun Chen;J. Ji;R. Zhou;Jinxia Liu;Wen-Kai Ni;L. Qu;H. Ni;R. Ni;B. Bao;Mingbing Xiao
中科院分区：
文献类型：
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作者：
Hongpei Wu;Xiaojun Chen;J. Ji;R. Zhou;Jinxia Liu;Wen-Kai Ni;L. Qu;H. Ni;R. Ni;B. Bao;Mingbing Xiao
胰腺癌（PC）是一种恶性程度较高的消化系统肿瘤，发病率呈上升趋势，预后差，5年生存率较低。绝大多数PC患者在诊断时已处于晚期，已经失去了根治性手术的机会。 PC的放疗和化疗疗效很差。因此，探讨PC的发生机制和新的治疗靶点具有重要意义。外泌体是介导细胞间物质和信息交换的细胞外囊泡。近年来，外泌体已被证明在 PC 的发生和进展中发挥着关键作用，并可能对其诊断和治疗有用。本文综述了外泌体的组成和功能及其在 PC 的发生、诊断和治疗中的作用。
Pancreatic cancer (PC) is a digestive system tumor that is highly malignant, with an increasing incidence rate, poor prognosis, and a low 5-year survival rate. The overwhelming majority of patients with PC are in an advanced stage at the time of diagnosis and have lost the opportunity for radical surgery. The efficacy of radiotherapy and chemotherapy for PC is very poor. Therefore, it is of great significance to explore the mechanisms of PC development and new therapeutic targets. Exosomes are extracellular vesicles that mediate the exchange of substances and information between cells. In recent years, exosomes have been shown to play a key role in the development and progression of PC and might be useful for both its diagnosis and treatment. This article reviews the composition and function of exosomes and their roles in the development, diagnosis, and treatment of PC.