Zinc transport in mammalian cells.
Zinc transport in mammalian cells.
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DOI：
10.1152/ajpcell.1996.270.2.c401
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发表时间：
1996-02
期刊：
影响因子：
--
通讯作者：
J. Reyes
中科院分区：
文献类型：
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作者：
J. Reyes
锌在细胞生理学中的重要性主要与其在细胞内参与酶催化、蛋白质结构、蛋白质-蛋白质相互作用和蛋白质-寡核苷酸相互作用有关。Zn 2+进入哺乳动物细胞的机制已经在多种细胞系统中进行了研究。该文献的综述表明，在所有细胞中，Zn 2+与细胞外结合位点相互作用，所述细胞外结合位点可能包括参与该离子随后易位到细胞内部的结合位点。在细胞内，Zn 2+结合到细胞溶质和细胞器结合位点或被细胞内细胞器吸收。尽管有这些一般性的结论，不同的运输和结合步骤的机制，对于大多数细胞类型，只有部分解决。这篇综述批判性地讨论了哺乳动物锌离子转运的文献，并概述了未来研究的关键点，这种离子的运输机制。
The importance of zinc in cell physiology is related mainly to its intracellular involvement in enzyme catalysis, protein structure, protein-protein interactions, and protein-oligonucleotide interactions. The mechanisms by which Zn2+ enters mammalian cells have been studied in a variety of cell systems. A review of this literature indicates that, in all cells, Zn2+ interacts with extracellular binding sites, which are likely to include binding sites involved in the subsequent translocation of this ion to the cell interior. Inside the cell, Zn2+ binds to cytosolic and organelle binding sites or is taken up by intracellular organelles. Despite these general conclusions, the mechanisms of the different transport and binding steps are, for most cell types, only partially solved. This review critically discusses the literature on mammalian Zn2+ transport and outlines some critical points for future research of the mechanisms of transport of this ion.