Reprogramming the tumor microenvironment by genome editing for precision cancer therapy.
Reprogramming the tumor microenvironment by genome editing for precision cancer therapy.
复制标题
通过基因组编辑重新编程肿瘤微环境，用于精确的癌症治疗。
DOI：
10.1186/s12943-022-01561-5
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发表时间：
2022-04-11
期刊：
影响因子：
37.3
通讯作者：
Yin JY
中科院分区：
文献类型：
--
作者：
Liu K;Cui JJ;Zhan Y;Ouyang QY;Lu QS;Yang DH;Li XP;Yin JY
肿瘤微环境（TME）对于肿瘤细胞的免疫逃生至关重要。它在肿瘤发育和转移中起着至关重要的作用。肿瘤的临床结果通常与患者TME的个体差异密切相关。因此，重编程TME细胞及其细胞间通信是癌症治疗的有吸引力且有希望的策略。 TME细胞由免疫和非免疫细胞组成。这些细胞需要精确，安全地操纵以改善癌症治疗。此外，令人鼓舞的是，近年来，随着基因编辑技术的出现和发展，该领域已经迅速发展。在这篇综述中，我们简要介绍了基因编辑技术，并系统地总结了其在TME中进行精密癌症治疗的应用，包括重新编程TME细胞及其细胞间通信。 TME细胞重编程可以调节细胞分化，增殖和功能。此外，重编程TME细胞的细胞间通信可以优化免疫浸润和免疫细胞对肿瘤细胞的特定识别。因此，基因编辑将为精确癌症治疗的进一步突破铺平道路。
The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays essential roles in tumor development and metastasis. The clinical outcomes of tumors are often closely related to individual differences in the patient TME. Therefore, reprogramming TME cells and their intercellular communication is an attractive and promising strategy for cancer therapy. TME cells consist of immune and nonimmune cells. These cells need to be manipulated precisely and safely to improve cancer therapy. Furthermore, it is encouraging that this field has rapidly developed in recent years with the advent and development of gene editing technologies. In this review, we briefly introduce gene editing technologies and systematically summarize their applications in the TME for precision cancer therapy, including the reprogramming of TME cells and their intercellular communication. TME cell reprogramming can regulate cell differentiation, proliferation, and function. Moreover, reprogramming the intercellular communication of TME cells can optimize immune infiltration and the specific recognition of tumor cells by immune cells. Thus, gene editing will pave the way for further breakthroughs in precision cancer therapy.
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