D3 dopamine receptors in rat spinal cord:: implications for sensory and motor function
D3 dopamine receptors in rat spinal cord:: implications for sensory and motor function
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DOI：
10.1016/s0304-3940(01)01692-5
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发表时间：
2001-04-27
影响因子：
2.5
通讯作者：
McCarson, KE
中科院分区：
文献类型：
--
作者：
Levant, B;McCarson, KE
使用定量放射自显影术确定大鼠脊髓中 D-3 受体的分布，并将其与 D-1 样和 D-2（和 D-4）受体的分布进行比较。 [H-3]PD 128907 标记的 D-3 位点的密度比 [H-3]螺哌隆标记的 D-2 (D-4) 位点的密度低大约 6 倍，比 [H-3]SCH 23390 标记的 D-1 样位点的密度低 60 倍。在颈椎和腰椎水平的背角浅层中观察到 Dg 结合密度最高，其次是中央部和背角。在腹角中检测到 D-3 位点密度最低。这些观察结果表明，脊髓 D-3 受体可能在感觉和/或运动功能中发挥作用，或者有助于多巴胺能药物的药理作用。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
Quantitative autoradiography was used to determine the distribution of D-3 receptors in rat spinal cord and compare it with the distribution of D-1-like and D-2 (and D-4) receptors. [H-3]PD 128907-labeled D-3 sites were observed in roughly 6-fold lower density than [H-3]spiperone-labeled D-2 (D-4) sites and 60-fold lower density than [H-3]SCH 23390-labeled D-1-like sites. Highest densities of Dg binding were observed in the superficial layers of the dorsal horn at cervical and lumbar levels followed by the pars centralis and dorsal horn. Lowest densities of D-3 sites were detected in the ventral horn. These observations suggest that spinal D-3 receptors may play a role in sensory and/or motor function or contribute to the pharmacological effects of dopaminergic drugs. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.