High Levels of Iron Status and Oxidative Stress in Patients with Metabolic Syndrome
High Levels of Iron Status and Oxidative Stress in Patients with Metabolic Syndrome
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DOI：
10.1007/s12011-012-9525-3
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发表时间：
2013-01-01
影响因子：
3.9
通讯作者：
Arredondo, Miguel A.
中科院分区：
文献类型：
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作者：
Leiva, Elba;Mujica, Veronica;Arredondo, Miguel A.
关于氧化应激（OxE）参数的研究有所增加，主要是因为其在心血管疾病和糖尿病并发症中的重要作用。本研究的主要目的是评估铁营养状况和氧化应激参数的主题已发展为代谢综合征（MetS）。研究了来自心血管疾病风险因素研究项目的受试者（n = 155）（年龄范围为45 - 65岁），并根据成人治疗组III标准进行分类。空腹12小时后采集血样，测定基础血糖、胰岛素、硫代巴比妥酸反应物质（TBARS）、氧化低密度脂蛋白（oxLDL）、血红素加氧酶（HO）活性、血脂和铁营养状况。85名受试者被归类为MetS，70名非MetS。代谢综合征患者表现出较高的铁储存（高水平的铁蛋白，全身铁和低转铁蛋白受体），oxLDL，TBARS和稳态模型评估胰岛素抵抗水平。MetS组显示高水平的氧化应激参数（HO活性、oxLDL和TBARS）。MetS的存在显示与LDL氧化风险相关（根据性别和年龄的多元线性回归，p < 0.001）。高水平的甘油三酯（p < 0.001）和腰围（p < 0.012）与oxLDL水平相关，TBARS和oxLDL与铁蛋白水平相关。通过逻辑回归分析，最高四分位数的铁蛋白与三倍的风险发展代谢综合征相比，最低的四分位数;此外，TBARS显示出21倍的风险发展代谢综合征。最后，氧化应激参数水平升高，如oxLDL，TBARS，HO和Fe储存与MetS相关。
Studies concerning oxidative stress (OxE) parameters have increased, mainly because of its important role in cardiovascular diseases and diabetes complications. The main objective of this study was to evaluate iron nutrition status and oxidative stress parameters in subjects that had developed metabolic syndrome (MetS). Subjects from the Research Program of Risk Factors for Cardiovascular Disease (n = 155) were studied (ages ranging from 45 to 65 years old) and classified according to the Adult Treatment Panel III criterion. A blood sample was taken after a 12-h fasting period, and basal glucose, insulin, thiobarbituric acid reactive substances (TBARS), oxidized LDL (oxLDL), heme oxygenase (HO) activity, lipid profile, and iron nutrition status were determined. Eighty-five subjects were classified as MetS, and 70 non-MetS. Individuals with MetS showed higher Fe storage (high levels of ferritin, total body iron and low transferrin receptor), oxLDL, TBARS, and homeostatic model assessment for insulin resistance levels. The MetS group showed high levels of oxidative stress parameters (HO activity, oxLDL, and TBARS). The presence of MetS showed an association with LDL oxidation risk (multiple lineal regression according to sex and age, p < 0.001). High levels of triglycerides (p < 0.001) and waist circumference (p < 0.012) were associated with oxLDL levels, as well as an association between TBARS and oxLDL with ferritin levels. Through logistic regression analyses, the highest quartile of ferritin was associated with a threefold risk of developing MetS compared to the lowest quartile; also, TBARS showed a 21-fold risk for the development of MetS. Finally, elevated levels of oxidative stress parameters such us oxLDL, TBARS, HO, and Fe storage were associated to MetS.