Pivotal Roles of ILCs in Hepatic Diseases
Pivotal Roles of ILCs in Hepatic Diseases
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DOI：
10.3109/08830185.2015.1008631
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发表时间：
2015-03
影响因子：
5
通讯作者：
Shuang Yang;Z. Tian;Yuzhang Wu;J. V. van Velkinburgh;B. Ni
中科院分区：
文献类型：
--
作者：
Shuang Yang;Z. Tian;Yuzhang Wu;J. V. van Velkinburgh;B. Ni
先天性淋巴样细胞（ILC）参与粘膜相关淋巴组织的发育，并作为效应细胞因子的快速和早期来源，这些效应细胞因子通常与T辅助细胞亚群相关，以响应病原体诱导的微环境变化。最近的研究表明，ILC是炎症相关肝病，特别是肝炎、纤维化和肝癌的潜在促发因素。本文就ILC在肝脏疾病中的作用进行综述，旨在为阐明ILC在正常和疾病状态下的特性以及提供具有治疗潜力的干预靶点提供参考。
Innate lymphoid cells (ILCs) are involved in the development of mucosal-associated lymphoid tissues and serve as a rapid and early source of the effector cytokines that are typically associated with the T helper cell subsets in response to pathogen-induced changes in the microenvironment. Recent research has implicated ILCs as potential contributing factors to the spectrum of inflammation-related hepatic diseases, particularly hepatitis, fibrosis and carcinoma. In this review, we summarize the current knowledge on the roles of ILCs in these hepatic pathogeneses, providing insights into the underlying cellular and signaling mechanisms to help guide the future research to elucidate the ILCs’ characters under normal and diseased conditions and provide interventional targets with therapeutic potential.