Antibiotic resistance patterns in invasive group B streptococcal isolates.
Antibiotic resistance patterns in invasive group B streptococcal isolates.
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DOI：
10.1155/2008/727505
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发表时间：
2008
影响因子：
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通讯作者：
Lynfield, Ruth
中科院分区：
文献类型：
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作者：
Castor, Mei L;Whitney, Cynthia G;Como-Sabetti, Kathryn;Facklam, Richard R;Ferrieri, Patricia;Bartkus, Joanne M;Juni, Billie A;Cieslak, Paul R;Farley, Monica M;Dumas, Nellie B;Schrag, Stephanie J;Lynfield, Ruth
抗生素用于 B 族链球菌 (GBS) 的预防和治疗。 1996 年至 2003 年期间，四个州对侵袭性 GBS 疾病进行了基于人群的积极监测。在 3813 例病例分离株中，91.0% (3471) 进行了血清分型，77.1% (2937) 进行了药敏检测，46.6% (3471) 进行了两种检测。所有患者均对青霉素、氨苄青霉素、头孢唑啉、头孢噻肟和万古霉素敏感。克林霉素和红霉素耐药性分别为 12.7% 和 25.6%，且与血清型 V 相关（P < .001）。克林霉素耐药性从 10.5% 增加至 15.0%（趋势 12.70 为 X 2；P < .001）；诱导性克林霉素耐药性与 erm 基因型相关。红霉素耐药性从 15.8% 增加至 32.8%（趋势 55.46 为 X 2；P < .001）。虽然 GBS 仍然对 β-内酰胺敏感，但对红霉素和克林霉素等替代药物的耐药性日益引起人们的关注。
Antibiotics are used for both group B streptococcal (GBS) prevention and treatment. Active population-based surveillance for invasive GBS disease was conducted in four states during 1996–2003. Of 3813 case-isolates, 91.0% (3471) were serotyped, 77.1% (2937) had susceptibility testing, and 46.6% (3471) had both. All were sensitive to penicillin, ampicillin, cefazolin, cefotaxime, and vancomycin. Clindamycin and erythromycin resistance was 12.7% and 25.6%, respectively, and associated with serotype V (P < .001). Clindamycin resistance increased from 10.5% to 15.0% (X 2 for trend 12.70; P < .001); inducible clindamycin resistance was associated with the erm genotype. Erythromycin resistance increased from 15.8% to 32.8% (X 2 for trend 55.46; P < .001). While GBS remains susceptible to beta-lactams, resistance to alternative agents such as erythromycin and clindamycin is an increasing concern.