CYCLINS AND CYCLIN-DEPENDENT KINASES - TAKE YOUR PARTNERS
CYCLINS AND CYCLIN-DEPENDENT KINASES - TAKE YOUR PARTNERS
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DOI：
10.1016/0968-0004(93)90185-p
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发表时间：
1993-06-01
影响因子：
13.8
通讯作者：
PINES, J
中科院分区：
文献类型：
--
作者：
PINES, J
在细胞周期研究的开始阶段，有cdc2。 cdc2基因在裂殖酵母裂殖酵母中被发现，因为它的突变具有导致细胞周期在两个离散点之一停止的不寻常特性：要么在起始点（细胞致力于DNA复制），要么在有丝分裂之前。 cdc2 基因编码 34 kDa 蛋白丝氨酸/苏氨酸激酶，并且在进化过程中高度保守。因此，看来相同的蛋白激酶负责调节细胞周期的“开始”和“结束”。如何？ cdc2 似乎在细胞周期的不同部分被细胞周期蛋白家族的不同成员结合和激活。 G1 细胞周期蛋白在 START 处调节 cdc2 活性，而有丝分裂（B 型）细胞周期蛋白在有丝分裂处调节 cdc2（参见参考文献 I, 2）。这种戏剧性的过度简化在 yeasP.% 中基本上是正确的，但在多细胞生物中则不然。
In the beginning-of cell cycle research-there was cdc2. The cdc2 gene was identified in the fission yeast Schizosaccharomyces pombe because its mutations had the unusual property of causing the cell cycle to stop at one of two discrete points: either at START, which is where a cell commits itself to DNA replication, or just before mitosis. The cdc2 gene encodes a 34 kDa protein serine/threonine kinase, and is highly conserved through evolution. Thus it appeared that the same protein kinase was responsible for regulating the'beginning'and the'end'of the cell cycle. How? It seems that cdc2 is bound and activated by different members of the cyclin family of proteins in different parts of the cell cycle. G1 cyclins regulate cdc2 activity at START, whereas mitotic (B-type) cyclins regulate cdc2 at mitosis (reviewed in Refs I, 2). This dramatic oversimplification is substantially true in yeasP.% but not in multicellular organisms.