Ligand-free gadolinium oxide for in vivo T1-weighted magnetic resonance imaging
Ligand-free gadolinium oxide for in vivo T1-weighted magnetic resonance imaging
复制标题
用于体内 T1 加权磁共振成像的无配体氧化钆
DOI：
10.1039/c3cp51530c
复制
发表时间：
2013-01-01
影响因子：
3.3
通讯作者：
Li, Li
中科院分区：
文献类型：
--
作者：
Luo, Ningqi;Tian, Xiumei;Li, Li
氧化钆（Gd 2 O3）作为一种T-1加权磁共振成像（MRI）造影剂，近年来受到广泛关注。本文采用一种简单的绿色方法，即在去离子水中用微秒激光烧蚀钆（Gd）靶，合成了直径为7.1 nm的无配体单斜晶系Gd 2 O 3纳米晶。这些纳米晶体获得了5.53 s（-1）mM（-1）的高r（1）弛豫率，并且通过S18细胞的细胞活力和RAW264.7细胞的凋亡证明了它们的低毒性。体外和体内MR图像显示这些颗粒是良好的T-1加权MRI造影剂。根据实验结果和理论分析，我们认为Gd_2O_3的高弛豫率与其纯度有关，而低毒性则与其结晶性有关。这些研究结果表明，在液体中的激光消融（LAL）是一个很有前途的策略，合成无配体的单斜晶系的Gd 2 O3纳米晶体用作高效的T-1加权MRI造影剂。
Gadolinium oxide (Gd2O3), which can be used as a T-1-weighted magnetic resonance imaging (MRI) contrast agent, has attracted intense attention in recent years. In this paper, ligand-free monoclinic Gd2O3 nanocrystals of 7.1 nm in diameter are synthesized by a simple and green approach, namely microsecond laser ablation of a gadolinium (Gd) target in deionized water. These nanocrystals obtain high r(1) relaxivity of 5.53 s(-1) mM(-1), and their low toxicity was demonstrated by the cell viability of S18 cells and apoptosis in RAW264.7 cells. In vitro and in vivo MR images show these particles to be good T-1-weighted MRI contrast agents. Base on the experimental results and theoretical analysis, we suggest that the purity of the Gd2O3 contributes to its high r(1) relaxivity value, while the low toxicity is due to its good crystallinity. These findings show that laser ablation in liquid (LAL) is a promising strategy to synthesize ligand-free monoclinic Gd2O3 nanocrystals for use as high efficient T-1-weighted MRI contrast agents.