Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B, and Other Diketopiperazines Produced by Aspergillus fumigatus. Part 2. Physico‐ Chemical Properties and Structures.
Novel Mammalian Cell Cycle Inhibitors, Tryprostatins A, B, and Other Diketopiperazines Produced by Aspergillus fumigatus. Part 2. Physico‐ Chemical Properties and Structures.
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烟曲霉产生的新型哺乳动物细胞周期抑制剂、胰前列腺素 A、B 和其他二酮哌嗪。第 2 部分。物理化学性质和结构。
DOI：
10.1002/chin.199647268
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
H. Osada
中科院分区：
文献类型：
--
作者：
C. Cui;H. Kakeya;H. Osada
从烟曲霉（Aspergillusfumigatus）的次级代谢产物中分离得到两个新的二酮哌嗪类化合物，即前列腺素A和B，以及四个已知的二酮哌嗪类化合物，即烟曲霉素C、12，13-二羟基烟曲霉素C、烟曲霉素B和verruculogen，均为新的细胞周期M期抑制剂。本文主要用波谱学方法，特别是用脉冲场梯度异质结多键相关（PFG-HMBC）等2DNMR技术，对Tryprostatin A、B和demethoxyfumitavergin C的X和13 CNMR谱进行了详细的分析，确定了它们的结构。根据旋光值和CD谱确定了它们的绝对构型。
Twonovel diketopiperazines namedtryprostatins Aand Band a newnatural product belonging to the diketopiperazine series, designated as demethoxyfumitremorgin C, together with four known diketopiperazines, fumitremorgin C, 12, 13-dihydroxyfumitremorgin C, fumitremorgin B and verruculogen, are newMphase inhibitors of the mammaliancell cycle, whichwere isolated from the secondary metabolites of Aspergillus fumigatus. The structures of tryprostatins A, Band demethoxyfumitremorgin C were determined mainly by the use of spectroscopic methods especially by detailed analyses of their XHand 13CNMRspectra with the aid of2DNMRtechniques including pulse field gradient heteronuclear multiple-bond correlation (PFG-HMBC) spectroscopy. Their absolute configurations weredetermined on the basis of the optical rotational values and CDspectra.