Alterations in neural circuits underlying emotion regulation following child maltreatment: a mechanism underlying trauma-related psychopathology.
Alterations in neural circuits underlying emotion regulation following child maltreatment: a mechanism underlying trauma-related psychopathology.
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DOI：
10.1017/s0033291720000641
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发表时间：
2021-08
影响因子：
6.9
通讯作者：
McLaughlin KA
中科院分区：
文献类型：
--
作者：
Jenness JL;Peverill M;Miller AB;Heleniak C;Robertson MM;Sambrook KA;Sheridan MA;McLaughlin KA
情绪调节（ER）神经回路的中断可能是儿童虐待与精神病理学联系的机制。我们研究了虐待与神经反应的关联，在被动观看负面情绪刺激和试图调节情绪反应。我们调查了虐待对ER期间神经激活的影响是否在整个发育过程中存在差异，以及脑功能的改变是否介导了虐待与潜在的一般精神病理学（“p”）因素之间的关联。年龄在8-16岁的青少年（n = 79）和没有（n = 72）暴露于虐待完成了ER任务，评估神经反应，在被动观看消极和中性的图像和努力尝试调节情绪反应的负面刺激。P-因子评分由包含内化和外化精神病理学的双因子模型定义。受虐待的青少年有更大的激活左侧杏仁核和显着性处理区域和减少激活多个区域参与认知控制（双侧上级回，额中回，背侧前扣带皮层）时，观看消极与中性图像比青年没有虐待曝光。认知控制区神经募集减少介导了全脑分析中虐待与p因子的关联。虐待青年表现出增加招聘随着年龄的增长，在腹外侧前额叶皮层在重新评估，而对照组的参与者表现出减少招聘随着年龄的增长。在调整了共同发生的忽视后，结果相似。儿童虐待的影响发展与显着性处理和认知控制在ER的方式，有助于精神病理学。
Disruptions in neural circuits underlying emotion regulation (ER) may be a mechanism linking child maltreatment with psychopathology. We examined the associations of maltreatment with neural responses during passive viewing of negative emotional stimuli and attempts to modulate emotional responses. We investigated whether the influence of maltreatment on neural activation during ER differed across development and whether alterations in brain function mediated the association between maltreatment and a latent general psychopathology (‘p’) factor. Youth aged 8–16 years with (n = 79) and without (n = 72) exposure to maltreatment completed an ER task assessing neural responses during passive viewing of negative and neutral images and effortful attempts to regulate emotional responses to negative stimuli. P-factor scores were defined by a bi-factor model encompassing internalizing and externalizing psychopathology. Maltreated youth had greater activation in left amygdala and salience processing regions and reduced activation in multiple regions involved in cognitive control (bilateral superior frontal gyrus, middle frontal gyrus, and dorsal anterior cingulate cortex) when viewing negative v. neutral images than youth without maltreatment exposure. Reduced neural recruitment in cognitive control regions mediated the association of maltreatment with p-factor in whole-brain analysis. Maltreated youth exhibited increasing recruitment with age in ventrolateral prefrontal cortex during reappraisal while control participants exhibited decreasing recruitment with age. Findings were similar after adjusting for co-occurring neglect. Child maltreatment influences the development of regions associated with salience processing and cognitive control during ER in ways that contribute to psychopathology.