Drug delivery during pregnancy: evaluation in vitro of new drugs.
Drug delivery during pregnancy: evaluation in vitro of new drugs.
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妊娠期间的药物输送：新药的体外评价。
DOI：
10.1071/rd9951485
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Liebes,L
中科院分区：
文献类型：
--
作者：
Dancis,J;Liebes,L
治疗孕妇的适应症大致分为三类：母亲和婴儿需要治疗，只有母亲需要治疗，或者只有婴儿需要治疗。针对受影响的对象进行治疗是良好护理的一个重要方面，尽管这不是唯一的方面。有人认为，在精选的实验室检查(包括胎盘灌注)和胎盘生理学知识的帮助下，可以在不危及母亲或婴儿的情况下合理选择适当的药物。文中给出了支持这一观点的例子。简要讨论了羊膜腔内给药。呼吁开发专门为怀孕期间使用的药物。
Indications for the treatment of the pregnant woman fall into three general categories: mother and infant require treatment, only the mother should be treated, or only the infant. Directing therapy towards the affected subject is an important aspect of good care, although it is not the only one. It is argued that a rational selection of the appropriate drug can be made without endangering mother or infant, with the aid of select laboratory investigations, including placental perfusion, and a knowledge of placental physiology. Examples are presented to support this contention. The intra-amniotic administration of drugs is briefly discussed. A plea is made to develop drugs that are designed specifically for use during pregnancy.