Alterations of resting-state functional network centrality in patients with asthma: evidence from a voxel-wise degree centrality analysis
Alterations of resting-state functional network centrality in patients with asthma: evidence from a voxel-wise degree centrality analysis
复制标题
哮喘患者静息态功能网络中心性的改变：来自体素程度中心性分析的证据
DOI：
10.1097/wnr.0000000000001087
复制
发表时间：
2018-09-26
期刊：
影响因子：
1.7
通讯作者：
Wang, Jun
中科院分区：
文献类型：
--
作者：
Li, Qiu-Gen;Zhou, Fu-Qing;Wang, Jun
先前的几项研究报道了哮喘患者的大脑活动异常，而静息状态网络的变化仍然未知。本研究的目的是利用体素度中心性（DC）方法研究哮喘患者功能网络中心性的变化。哮喘患者和健康对照（hc）在年龄、性别和受教育程度上非常接近。采用DC法对功能网络中心性进行评价。采用受试者工作特征曲线来区分哮喘组和hc组。采用Pearson相关系数探讨不同脑区DC均值与行为表现的关系。与hc相比，哮喘患者右侧颞中回和右侧壳核的DC值明显降低。哮喘患者的右小脑后叶、右侧颞下回、左侧额上回、左侧中央后回及顶叶下小叶、左侧额中回、左侧中央后回的DC值明显升高。然而，观察到的不同脑区的平均DC值与行为表现之间没有关系。结果表明，哮喘患者的DC值在不同的脑区发生改变，这些脑区与默认模式网络、皮层-基底神经节网络、额顶叶网络和感觉运动网络有关，为哮喘患者的临床研究提供了一些有用的信息。
Several previous studies have reported that asthma patients have abnormal brain activities, whereas alterations in the resting-state network still remain unknown. The aim of this study was to investigate the changes in functional network centrality in asthma patients using voxel-wise degree centrality (DC) method. Asthma patients and healthy controls (HCs) were matched closely in age, sex, and education of participants. The DC method was used to evaluate the functional network centrality. The receiver operating characteristic curve was used to distinguish the asthma group from the HCs group. The Pearson correlation coefficient was used to explore the relationship between the observed mean values of DC in different brain areas and the behavioral performance. Compared with HCs, DC values were significantly decreased in the right middle temporal gyrus and the right putamen of asthma patients. In contrast, in asthma patients, DC values were markedly increased in the right posterior lobe of the cerebellum, right inferior temporal gyrus, left superior frontal gyrus, left postcentral gyrus and inferior parietal lobule, left middle frontal gyrus, and left postcentral gyrus. However, there was no relationship between the observed mean DC values in different brain areas and the behavioral performance. The results showed that the DC values were altered in various brain regions of asthma patients, which were related to default mode network, the cortex–basal ganglia network, the frontoparietal network, and the sensorimotor network, leading to some useful information for clinical studies in asthma patients.