Decreased short-interval intracortical inhibition correlates with better pinch strength in patients with stroke and good motor recovery.
Decreased short-interval intracortical inhibition correlates with better pinch strength in patients with stroke and good motor recovery.
复制标题
短间隔皮质内抑制的减少与中风患者更好的捏力和良好的运动恢复相关。
DOI：
10.1016/j.brs.2018.01.030
复制
发表时间：
2018
影响因子：
7.7
通讯作者：
Conforto,AdrianaBastos
中科院分区：
文献类型：
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作者：
FerreirodeAndrade,KarinaNocelo;Conforto,AdrianaBastos
背景深度短间隔皮质内抑制 (SICI) 是 GABAA 活性的标志物，与中风后慢性期中度至重度手部损伤的患者更好的运动表现相关。 目的我们评估了受影响半球的 SICI 与康复良好患者的麻痹手捏力之间的相关性。我们还研究了对照中 SICI 和捏力之间的相关性。方法 本研究包括 22 名受试者。 SICI 采用配对脉冲范例进行测量。使用 Spearman's rho 评估侧向捏力与 SICI 之间的相关性。结果 在患者中，SICI 与捏力之间存在显着相关性（rho=0.69，p=0.014），但在对照组中则不然。手部无力程度较大的患者 SICI 明显更深。结论这些初步研究结果表明，M1AH 中 GABAA 活性的降低与恢复良好的慢性期中风受试者更好的手部运动表现相关。
BackgroundDeeper short-interval intracortical inhibition (SICI), a marker of GABAAactivity, correlates with better motor performance in patients with moderate to severe hand impairments in the chronic phase after stroke.ObjectivesWe evaluated the correlation between SICI in the affected hemisphere and pinch force of the paretic hand in well-recovered patients. We also investigated the correlation between SICI and pinch force in controls.MethodsTwenty-two subjects were included in the study. SICI was measured with a paired-pulse paradigm. The correlation between lateral pinch strength and SICI was assessed with Spearman's rho.ResultsThere was a significant correlation (rho = 0.69, p = 0.014) between SICI and pinch strength in patients, but not in controls. SICI was significantly deeper in patients with greater hand weakness.ConclusionsThese preliminary findings suggest that decreased GABAAactivity in M1AHcorrelates with better hand motor performance in well-recovered subjects with stroke in the chronic phase.