Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization.
Epigenetic regulations through DNA methylation and hydroxymethylation: clues for early pregnancy in decidualization.
复制标题
通过DNA甲基化和羟甲基化的表观遗传学调节：截断性早期妊娠的线索。
DOI：
10.1515/bmc-2013-0036
复制
发表时间：
2014-05
影响因子：
--
通讯作者：
Das SK
中科院分区：
文献类型：
--
作者：
Gao F;Das SK
DNA胞嘧啶甲基化是一种重要的表观遗传修饰，在不改变原始DNA序列的情况下参与基因表达调控。随着高通量测序技术的快速发展，甲基化胞嘧啶的全基因组分布及其调控机制逐渐被揭示。这使得揭示DNA甲基化在维持细胞多能性、发育过程中决定细胞命运和各种疾病中所起的关键作用。最近，5-羟甲基胞嘧啶和其他类型的DNA修饰的重新发现，揭示了细胞甲基化调控的更多动态方面。DNA甲基化和其他表观遗传变化的相互作用重塑了染色质结构，并决定了基因转录的状态，不仅是永久的，而且在某些刺激下也是短暂的。子宫是一个生殖器官，在发情周期和妊娠期间经历显着的激素刺激的变化，因此为我们提供了一个独特的模型，研究表观遗传修饰的动态调节。本文就基因组DNA甲基化和羟甲基化在基因表达调控中的作用进行综述，并对这些表观遗传学变化在着床和蜕膜化过程中的研究进展进行讨论。
DNA methylation at cytosines is an important epigenetic modification that participates in gene expression regulation without changing the original DNA sequence. With the rapid progress of high-throughput sequencing techniques, whole-genome distribution of methylated cytosines and their regulatory mechanism have been revealed gradually. This has allowed the uncovering of the critical roles played by DNA methylation in the maintenance of cell pluripotency, determination of cell fate during development, and in diverse diseases. Recently, rediscovery of 5-hydroxymethylcytosine, and other types of modification on DNA, have uncovered more dynamic aspects of cell methylome regulation. The interaction of DNA methylation and other epigenetic changes remodel the chromatin structure and determine the state of gene transcription, not only permanently, but also transiently under certain stimuli. The uterus is a reproductive organ that experiences dramatic hormone stimulated changes during the estrous cycle and pregnancy, and thus provides us with a unique model for studying the dynamic regulation of epigenetic modifications. In this article, we review the current findings on the roles of genomic DNA methylation and hydroxymethylation in the regulation of gene expression, and discuss the progress of studies for these epigenetic changes in the uterus during implantation and decidualization.