Short-term vitamin A supplementation does not affect bone turnover in men
Short-term vitamin A supplementation does not affect bone turnover in men
复制标题
DOI：
10.1093/jn/132.6.1169
复制
发表时间：
2002-06-01
影响因子：
4.2
通讯作者：
Binkley, NC
中科院分区：
文献类型：
--
作者：
Kawahara, TN;Krueger, DC;Binkley, NC
人类和动物的有限数据表明，过量的维生素A刺激骨吸收并抑制骨形成，随着时间的推移可能导致骨质流失和骨折。因此，维生素A补充剂可能是目前未被认识到的骨质疏松症发生的危险因素。为了进一步评估这种可能性，我们对80名18-58岁的健康男性进行了一项补充维生素A的前瞻性、随机、单盲研究。其中一半的人每天在晚餐时服用7576杯（25,000 IU）的棕榈酸视黄醇;其他人服用安慰剂。从空腹受试者中采集血液，并在基线和补充2、4和6周后制备血清。测定各组大鼠血清骨特异性碱性磷酸酶（BSAP）和1型胶原N端肽（NTx）水平。在基线和补充6周后测定血清骨钙素（Oc）。在研究过程中，补充组和安慰剂治疗组之间的BSAP、NTx和Oc没有差异。总之，健康男性短期补充此剂量的维生素A不会改变骨骼周转的血清标志物。因此，短期服用维生素A不太可能导致骨质疏松症的发生。长期补充维生素A是否会对骨骼产生不良影响仍有待确定。
Limited data in humans and animals indicate that excess vitamin A stimulates bone resorption and inhibits bone formation, effects that over time might lead to bone loss and fracture. Thus, it is possible that vitamin A supplementation is a currently unrecognized risk factor for the development of osteoporosis. To further evaluate this possibility, a prospective, randomized, single-blind study of vitamin A supplementation was conducted in 80 healthy men age 18-58 y. One half received 7576 mug (25,000 IU) of retinol palmitate daily with their evening meal; the others took a placebo. Blood was collected from fasting subjects and serum prepared at baseline and after 2, 4 and 6 wk of supplementation. Serum bone specific alkaline phosphatase (BSAP) and N-Telopeptide of type 1 collagen (NTx) were measured at all time points. Serum osteocalcin (Oc) was measured at baseline and after 6 wk of supplementation. BSAP, NTx and Oc did not differ between the supplemented and placebo-treated groups over the course of the study. In conclusion, short-term vitamin A supplementation at this dosage in healthy men does not alter serum markers of skeletal turnover. Thus, it is unlikely that short-term administration of vitamin A would contribute to the development of osteoporosis. Whether long-term vitamin A supplementation might have adverse skeletal effects remains to be determined.