Functional Implications of the Golgi and Microtubular Network in Gonadotropes
Functional Implications of the Golgi and Microtubular Network in Gonadotropes
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高尔基体和微管网络在促性腺激素中的功能意义
DOI：
10.1016/j.mce.2013.10.003
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发表时间：
2014
影响因子：
4.1
通讯作者：
Ushiki T
中科院分区：
文献类型：
--
作者：
②Watanabe T;Bochimoto H;Koga D;Hosaka M;Ushiki T
与广泛接受的高尔基体杯状的图像相反，垂体促性腺激素细胞的高尔基体被组织成球形，其外表面和内表面分别是顺式和反式高尔基体元件。在球形高尔基体的中心，一对中心粒作为微管组织中心，辐射状微管从中心向细胞周边各向同性延伸。本文综述了高尔基体和微管网络在促性腺细胞中的特征性组织的意义，考虑了微管依赖的膜转运在高尔基体结构的形成和维持中的作用。由于高尔基体的高度对称的组织可能会受到干扰，在促性腺激素的实验治疗，在各种实验条件下，在促性腺激素的高尔基体结构的监测将是一种新的体内方法来阐明高尔基体的生物起源。
In contrast to the widely accepted images of the Golgi apparatus as a cup-like shape, the Golgi in pituitary gonadotropes is organized as a spherical shape in which the outer and inner faces are cis- and trans-Golgi elements, respectively. At the center of the spherical Golgi, a pair of centrioles is situated as a microtubule-organizing center from which radiating microtubules isotropically extend toward the cell periphery. This review focuses on the significance of the characteristic organization of the Golgi and microtubule network in gonadotropes, considering the roles of microtubule-dependent membrane transport in the formation and maintenance of the Golgi structure. Because the highly symmetrical organization of the Golgi is possibly perturbed in response to experimental treatments of gonadotropes, monitoring of the Golgi structure in gonadotropes under various experimental conditions will be a novel in vivo approach to elucidate the biogenesis of the Golgi apparatus.