INCIDENCE OF CORONARY HEART-DISEASE AND LIPOPROTEIN CHOLESTEROL LEVELS - THE FRAMINGHAM-STUDY
INCIDENCE OF CORONARY HEART-DISEASE AND LIPOPROTEIN CHOLESTEROL LEVELS - THE FRAMINGHAM-STUDY
复制标题
DOI：
10.1001/jama.256.20.2835
复制
发表时间：
1986-11-28
影响因子：
120.7
通讯作者：
KANNEL, WB
中科院分区：
文献类型：
--
作者：
CASTELLI, WP;GARRISON, RJ;KANNEL, WB
弗雷明翰研究的第一份报告证明了高密度脂蛋白胆固醇(HDLC)与冠心病(CHD)发病率之间的负相关关系，这是基于四年的监测。这些参与者的年龄在49岁到82岁之间，现在已经被随访了12年，这份报告表明，空腹高密度脂蛋白胆固醇水平与冠心病后续发病率之间的关系并没有随着时间的推移而明显减少。由于在最初测定8年后可进行第二次高密度脂蛋白-C测量，因此对同一受试者在两个时间点的高密度脂蛋白-C测量之间的关系进行了研究。第二个高密度脂蛋白-C测量也被用于包括吸烟、相对体重、饮酒量、原因血糖、总胆固醇和血压的多变量模型。结论是，即使在这些调整之后，在49岁及以上的男性和女性中，非空腹高密度脂蛋白胆固醇和总胆固醇水平与冠心病的发生有关。研究发现，与高密度脂蛋白胆固醇水平在第20个百分位数的受试者相比，高密度脂蛋白胆固醇水平在第80个百分位数的受试者患冠心病的风险降低了一半。
The first report from the Framingham Study that demonstrated an inverse relationship between high-density lipoprotein cholesterol (HDL-C) and the incidence of coronary heart disease (CHD) was based on four years of surveillance. These participants, aged 49 to 82 years, have now been followed up for 12 years, and this report shows that the relationship between the fasting HDL-C level and subsquent incidence of CHD does not diminish appreciably with time. Since a second measurement of HDL-C is available eight years after the initial determination, the relationship of HDL-C measurements on the same subjects at two points in time is examined. This second HDL-C measurement is also used in a multivariate model that includes cigarette smoking, relative weight, alcohol consumption, causal blood glucose, total cholesterol, and blood pressure. It is concluded that even after these adjustments, nonfasting HDL-C and total cholesterol levels are related to development of CHD in both men and women aged 49 years and older. Study participants at the 80th percentile of HDL-C were found to have half the risk of CHD developing when compared with subjects at the 20th percentile of HDL-C.