Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential
Red light-promoted skin barrier recovery: Spatiotemporal evaluation by transepidermal potential
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DOI：
10.1371/journal.pone.0219198
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发表时间：
2019-07-10
期刊：
影响因子：
3.7
通讯作者：
Nishizawa, Matsuhiko
中科院分区：
文献类型：
--
作者：
Abe, Yuina;Konno, Hajime;Nishizawa, Matsuhiko
以猪皮为实验材料，通过测定皮肤表面与真皮之间的电位差（TEP）的相关恢复来评价光促进皮肤表皮屏障的恢复。用40 mW/cm ~（2）的红光照射10 min以上，可加速TEP的恢复，并观察到光刺激对周围环境（20 mm）的影响。蓝色和紫色的光芒照射，对加速结界的恢复没有任何效果。光刺激的这些特性将有助于设计有效和安全的皮肤光疗装置。本研究证明，TEP可以作为表皮屏障功能的时空指标。
The light-promoted recovery of epidermal barrier of skin was evaluated by the associated recovery of transepidermal potential (TEP), the potential difference between the surface and dermis of skin, by using porcine skin samples. An accelerated recovery of TEP was observed by irradiation of red light with the irradiance of 40 mW/cm(2) and a duration of >10 min. The influence of the light stimulation to the surroundings (similar to 20 mm) was also observed. The irradiations of blue and purple lights were ineffective in accelerating the barrier recovery. These characteristics of the light stimulation would be useful for the design of effective and safe phototherapy devices for skin. The present study proves that the TEP can serve as a spatiotemporal indicator of the epidermal barrier function.