Mucin carbohydrate antigens (T, Tn, and sialyl-Tn) in human ovarian carcinomas: Relationship with histopathology and prognosis
Mucin carbohydrate antigens (T, Tn, and sialyl-Tn) in human ovarian carcinomas: Relationship with histopathology and prognosis
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DOI：
10.1016/s0046-8177(97)90012-5
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发表时间：
1997-08-01
期刊：
影响因子：
3.3
通讯作者：
Aihara, K
中科院分区：
文献类型：
--
作者：
Ghazizadeh, M;Ogawa, H;Aihara, K
卵巢癌中粘蛋白的糖基化改变导致T、Tn和唾液酸Tn抗原的表达，但其与预后的关系尚不清楚。我们用化学方法研究了38例卵巢癌（17例浆液性和21例粘液性）中这些抗原的表达，以评估其与疾病分期、肿瘤组织病理学和患者生存时间相比的潜在预后价值。8例良性卵巢肿瘤（4例浆液性和4例粘液性）和4例正常卵巢组织也进行了研究。在38例癌中，25例（66%）表达T，27例（71%）表达Tn，33例（87%）表达sialyl-Tn抗原。大多数病例（83%）同时表达三种抗原中的两种或全部。正常卵巢上皮细胞不表达这些抗原，而良性卵巢肿瘤的上皮细胞中只有不到25%表达这些抗原或为阴性，或偶见弱阳性。地区统计学分析显示Tn和唾液酸-Tn抗原表达与疾病分期以及组织学分级之间有很强的相关性。在19例有生存资料的卵巢癌患者中，Tn或sialyl-Tn抗原高表达患者的总生存时间明显低于阴性和低表达患者（P <0.05和P <0.01）。在多因素逐步回归分析中，发现疾病分期（P = 0.000）和Tn抗原表达（P = 0.02）是与总生存时间相关的重要独立参数。这些发现表明，除了T抗原的表达，Tn和唾液酸-Tn抗原在卵巢癌的表达可能提供额外的预后信息对患者的结果。版权所有（C）1997 W.B.桑德斯公司
Altered glycosylation of mucins leading to the expression of T, Tn, and sialyl-Tn antigens has been shown in ovarian carcinoma, but its relationship with prognosis is still unclear. We investigated immunohistochemically the expression of these antigens in 38 (17 serous and 21 mucinous) ovarian carcinomas to assess their potential prognostic value as compared with stage of disease, histopathology of tumors, and survival time of patients. Eight benign ovarian tumors (four serous and four mucinous), and four normal ovarian tissues also were studied. Of the 38 carcinomas, 25 (66%) expressed T, 27 (71%) expressed Tn, and 33 (87%) expressed sialyl-Tn antigens. Most cases (83%) expressed two or all of the three types of antigens simultaneously. Normal ovarian epithelia showed no staining for these antigens, and benign ovarian tumors were either negative or occasionally expressed weak staining in less than 25% of epithelial cell. areas. Statistical analyses showed strong associations between Tn and sialyl-Tn antigen expressions and disease stage as well as histological grade. In 19 ovarian carcinoma patients with available survival data, the overall survival times of patients with high Tn or sialyl-Tn antigen expression were significantly worse than those of the patients with negative and low expression (P < .05 and P < .01). In multivariate stepwise regression analysis, disease stage (P = .000) and Tn antigen expression (P = .02) were found to be significant independent parameters associated with the overall survival time. These finding suggest that, with exception of T antigen expression, the expression of Tn and sialyl-Tn antigens in ovarian carcinomas may provide additional prognostic information on patient outcome. Copyright (C) 1997 by W.B. Saunders Company.