SSP1, a gene necessary for proper completion of meiotic divisions and spore formation in Saccharomyces cerevisiae.
SSP1, a gene necessary for proper completion of meiotic divisions and spore formation in Saccharomyces cerevisiae.
复制标题
SSP1，一种在酿酒酵母中正确完成减数分裂和孢子形成所必需的基因。
DOI：
10.1128/mcb.17.12.7029
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发表时间：
1997
影响因子：
5.3
通讯作者：
Axelrod,J
中科院分区：
文献类型：
--
作者：
Nag,DK;Koonce,MP;Axelrod,J
During meiosis, a diploid cell undergoes two rounds of nuclear division following one round of DNA replication to produce four haploid gametes. In yeast, haploid meiotic products are packaged into spores. To gain new insights into meiotic development and spore formation, we followed differential expression of genes in meiotic versus vegetatively growing cells in the yeastSaccharomyces cerevisiae. Our results indicate that there are at least five different classes of transcripts representing genes expressed at different stages of the sporulation program. Here we describe one of these differentially expressed genes,SSP1, which plays an essential role in meiosis and spore formation.SSP1is expressed midway through meiosis, and homozygousssp1diploid cells fail to sporulate. In thessp1mutant, meiotic recombination is normal but viability declines rapidly. Both meiotic divisions occur at the normal time; however, the fraction of cells completing meiosis is significantly reduced, and nuclei become fragmented soon after meiosis II. Thessp1defect does not appear to be related to a microtubule-cytoskeletal-dependent event and is independent of two rounds of chromosome segregation. The data suggest that Ssp1 is likely to function in a pathway that controls meiotic nuclear divisions and coordinates meiosis and spore formation.
