Strontium substituted hydroxyapatites: Synthesis and determination of their structural properties, in vitro and in vivo performance
Strontium substituted hydroxyapatites: Synthesis and determination of their structural properties, in vitro and in vivo performance
复制标题
DOI：
10.1016/j.msec.2015.05.081
复制
发表时间：
2015-10-01
影响因子：
7.9
通讯作者：
Yakuphanoglu, Fahrettin
中科院分区：
文献类型：
--
作者：
Kaygili, Omer;Keser, Serhat;Yakuphanoglu, Fahrettin
本研究的目的是详细报道锶取代羟基磷灰石的合成和表征。基于此目的，羟基磷灰石（HAp）生物陶瓷具有不同量的锶（例如，0,0.45,0.90,135,1.80和2.25 at）。%)采用溶胶-凝胶法制备。采用x射线衍射（XRD）、傅里叶变换红外光谱（FTIR）和扫描电镜（SEM）技术，研究了Sr取代对样品结构性能和生物相容性的影响。所有样品由21 ~ 27 nm的纳米颗粒组成。低浓度锶的存在影响了HAp的晶体尺寸、结晶度、晶格参数和晶胞体积。体外条件和模拟体液（SBF）浸泡时间对这些特性有显著影响。特别是(Ca + Sr)/P摩尔比随着SBF中保温时间的增加而逐渐降低。动物实验结果表明，所有样品的骨形成和骨整合均良好，且Sr含量最低的样品与其他组相比更为合理。(C) 2015 Elsevier B.V.版权所有
The objective of this study is to present a detailed report related to the synthesis and characterization of strontium substituted hydroxyapatites. Based on this purpose, hydroxyapatite (HAp) bioceramics with different amounts of strontium (e.g., 0, 0.45, 0.90, 135, 1.80 and 2.25 at.%) were prepared using a sol-gel method. The effects of Sr substitution on the structural properties and biocompatibility of the samples were studied by X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) techniques, in vitro and in vivo tests. All the samples composed of the nanoparticles ranging from 21 to 27 nm. The presence of Sr at low levels influenced the crystal size, crystallinity degree, lattice parameters and volume of the unit cell of the HAp. Both in vitro conditions and soaking period in simulated body fluid (SBF) significantly affected these properties. Especially, the (Ca + Sr)/P molar ratio gradually decreases with increasing soaking period in SBF. Animal experiments revealed the bone formation and osseointegration for all samples, and as compared with other groups, more reasonable, were observed for the sample with the lowest Sr content. (C) 2015 Elsevier B.V. All rights reserved.