Effect of surface tension and surfactant administration on Eustachian tube mechanics
Effect of surface tension and surfactant administration on Eustachian tube mechanics
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DOI：
10.1152/japplphysiol.01123.2001
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发表时间：
2002-09-01
影响因子：
3.3
通讯作者：
Swarts, JD
中科院分区：
文献类型：
--
作者：
Ghadiali, SN;Banks, J;Swarts, JD
中耳炎的发生与咽鼓管(ET)机械结构异常有关。ET是一种可折叠的管子，定期打开以调节中耳压力，并将中耳积液清除到鼻咽。执行这些生理功能的能力取决于几个机械特性，包括ET的开启压力(P-OPEN)、顺应性(ETC)和滞后(ETA)。在这项研究中，以前开发的一种改进力-反应方案被用来在实验操作粘膜表面状况后确定ET的机械特性。具体地说，在基线条件下，对6只细胞学猴子的右耳的这些特性进行了测量，这些特性是在“洗掉”正常的ET粘膜层和注入肺表面活性物质InFasurf之后进行的。切除正常粘膜对P-OPEN无明显影响，但确实导致ETC和ETA降低(P<；0.05)。英法舒夫治疗能有效降低P-开放，并使ETC和ETA恢复到基线水平(P<；0.05)。这些结果表明，粘膜-空气的表面张力可以影响ET的总体ETC和ETA性质。此外，本研究表明，肺表面活性物质治疗可能只对硬性或非弹性ETS(大P-开放和低ETC和ETA)患者有益。
Development of otitis media has been related to abnormal Eustachian tube (ET) mechanics. ET is a collapsible tube that is periodically opened to regulate middle ear pressure and to clear middle ear fluid into the nasopharynx. The ability to perform these physiological functions depends on several mechanical properties, including the ET's opening pressure (P-open), compliance (ETC), and hysteresis (eta). In this study, a previously developed modified force-response protocol was used to determine ET mechanical properties after experimental manipulation of the mucosal surface condition. Specifically, these properties were measured in the right ear of six cynomologous monkeys under baseline conditions after "washing out" the normal ET mucous layer and after instillation of a pulmonary surfactant, Infasurf. Removal of the normal mucosa did not significantly alter P-open but did result in a decrease in ETC and eta (P < 0.05). Treatment of the mucosa with Infasurf was effective in reducing P-open and increasing both ETC and eta to baseline values (P < 0.05). These results indicate that the mucosa-air surface tension can affect the overall ETC and eta properties of the ET. In addition, this study indicates that surfactant therapy may only be beneficial in patients with rigid or inelastic ETs (large P-open and low ETC and eta).