Determinants of coagulation activation in humans.
Determinants of coagulation activation in humans.
复制标题
人类凝血激活的决定因素。
DOI：
10.1159/000217244
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Rosenberg,RD
中科院分区：
文献类型：
--
作者：
Bauer,KA;Eichinger,S;Mannucci,PM;Rosenberg,RD
为了评估体内产生因子VIla的机制，我们在给予血友病B患者纯化的因子IX浓缩物后测量了这种酶的水平。他们的因子VIla水平最初非常低，并逐渐增加到正常，但因子Xa或凝血酶的产生没有显着变化。向因子VII缺乏症患者给予10 μg/kg体重的重组因子Vila使循环水平增加35倍，但这仅导致因子IX和因子X的活化正常化。我们的数据表明，因子IXa是主要负责体内游离因子Vila的基础水平，并且血液中游离因子Vila的变化不一定导致因子X活化的改变。
To evaluate the mechanism responsible for the generation of factor VIla in vivo, we measured the levels of this enzyme after administering purified factor IX concentrates to patients with hemophilia B. Their factor VIla levels were initially very-low and gradually increased to normal, but there were no significant changes in the generation of factor Xa or thrombin. The administration of 10 μg/kg body weight of recombinant factor Vila to patients with factor VII deficiency increased the circulating levels 35-fold, but this only resulted in normalization of the activation of factor IX and factor X. Our data indicate that factor IXa is primarily responsible for the basal levels of free factor Vila in vivo, and that changes in free factor Vila in the blood do not necessarily lead to alterations in factor X activation.