Ribonuclease like 5 regulates zebrafish yolk extension by suppressing a p53-dependent DNA damage response pathway
Ribonuclease like 5 regulates zebrafish yolk extension by suppressing a p53-dependent DNA damage response pathway
复制标题
核糖核酸酶 5 通过抑制 p53 依赖性 DNA 损伤反应途径来调节斑马鱼卵黄延伸
DOI：
10.1016/j.biocel.2015.05.004
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发表时间：
2015
影响因子：
4
通讯作者：
Xu Zhengping
中科院分区：
文献类型：
--
作者：
Zhai Yixing;Zhao Xinyuan;Sheng Jinghao;Gao Xiangwei;Ou Zhao;Xu Zhengping
Ribonuclease like 5(Rnasel5) is a novel member of the zebrafish ribonuclease A family and its expression is increased during early embryogenesis. However, thein vivobiological function ofRnasel5remains to be elucidated. Here, we report that knockdown ofRnasel5by morhpolinos caused shrunken yolk extension as well as increased DNA damage at yolk syncytial layer and external tissue layers via the activation of p53 pathway. In addition, the morphological defects caused byRnasel5knockdown can be partially rescued by mRNA injection. Our findings provide the first functional characterization ofRnasel5in zebrafish development and reveal its critical role in yolk extension by modulation of the p53 pathway.
