Anaplasma phagocytophilum infection induces protracted neutrophil degranulation
Anaplasma phagocytophilum infection induces protracted neutrophil degranulation
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DOI：
10.1128/iai.72.6.3680-3683.2004
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发表时间：
2004-06-01
影响因子：
3.1
通讯作者：
Dumler, JS
中科院分区：
文献类型：
--
作者：
Choi, KS;Grab, DJ;Dumler, JS
嗜吞噬细胞无形体感染的中性粒细胞脱颗粒可加重炎症。因此，测定了感染的中性粒细胞的脱粒。感染的中性粒细胞表达CD 11b和CD 66 b，感染的中性粒细胞上清液显示出比对照组更强的proMMP-9和MMP-9活性，并持续大于或等于18 h。脱颗粒相关的炎性组织损伤可以解释人类粒细胞无形体病的一些临床表现。
Anaplasma phagocytophilum-infected neutrophil degranulation could exacerbate inflammation. Thus, the degranulation of infected neutrophils was assayed. Infected neutrophils expressed CD11b and CD66b, and supernatants of infected neutrophils showed more proMMP-9 and MMP-9 activity than controls and continued to do so for greater than or equal to18 h. Degranulation-related inflammatory tissue injury may account for some clinical manifestations in human granulocytic anaplasmosis.