ETS rearrangements and prostate cancer initiation.
ETS rearrangements and prostate cancer initiation.
复制标题
DOI：
10.1038/nature07738
复制
发表时间：
2009-02-12
期刊：
影响因子：
64.8
通讯作者：
Pandolfi, Pier Paolo
中科院分区：
文献类型：
--
作者：
Carver, Brett S.;Tran, Jennifer;Chen, Zhenbang;Carracedo-Perez, Arkaitz;Alimonti, Andrea;Nardella, Caterina;Gopalan, Anuradha;Scardino, Peter T.;Cordon-Cardo, Carlos;Gerald, William;Pandolfi, Pier Paolo
起源于：Tomlinset al.Nature448,595-599(2007)10.1038/Nature06024最近描述了前列腺癌中第一个反复发生的易位事件；它导致Ets(E26转化特异性)转录因子(ERGorETV1)易位到TMPRSS2启动子区域，该区域包含雄激素反应元件。TMPRSS2：ERG基因重排已被报道在大约40%的原发性前列腺癌中发生(ETV1基因重排发生的频率要低得多)，它导致雄激素调节的ERG、的异常表达。Tomlinset等人得出结论，ETS基因重排足以引发前列腺癌。然而，我们在这里表明，Ets基因重排实际上可能代表了前列腺癌发生的进展事件，而不是启动事件。为此，我们证明了前列腺特异性ERG的过度表达并不会引发前列腺癌的发生。
Arising from: Tomlinset al.Nature448, 595–599 (2007)10.1038/nature06024; Tomlinset al.replyThe first recurrent translocation event in prostate cancer has been recently described; it results in the translocation of an ETS (E26 transformation specific) transcription factor (ERGorETV1) to theTMPRSS2promoter region, which contains androgen responsive elements. TheTMPRSS2:ERGgenetic rearrangement has been reported to occur in approximately 40% of primary prostate tumours (ETV1genetic rearrangements occur at a much lower frequency), and it results in the aberrant androgen-regulated expression of ERG,,. Tomlinset al.concluded that ETS genetic rearrangements are sufficient to initiate prostate neoplasia. However, here we show that ETS genetic rearrangements may in fact represent progression events rather than initiation events in prostate tumorigenesis. To this end, we demonstrate that the prostate-specific overexpression of ERG does not initiate prostate tumorigenesis.
登录
查看更多内容
影响因子：
56.9
作者：
Tomlins, SA;Rhodes, DR;Chinnaiyan, AM
通讯作者：
Chinnaiyan, AM
影响因子：
5.6
作者：
Perner, Sven;Mosquera, Juan-Miguel;Rubin, Mark A.
通讯作者：
Rubin, Mark A.
影响因子：
7.5
作者：
Tu, Jiangling J.;Rohan, Stephen;Chen, Yao-Tseng
通讯作者：
Chen, Yao-Tseng
影响因子：
64.8
作者：
Tomlins, Scott A.;Laxman, Bharathi;Chinnaiyan, Arul M.
通讯作者：
Chinnaiyan, Arul M.