Inter- and intra-patient sequence diversity among parainfluenza virus-type 1 nucleoprotein genes.
Inter- and intra-patient sequence diversity among parainfluenza virus-type 1 nucleoprotein genes.
复制标题
副流感病毒 1 型核蛋白基因的患者间和患者内序列多样性。
DOI：
10.1023/a:1007973402749
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发表时间：
1997
期刊：
影响因子：
1.6
通讯作者：
Hurwitz,JL
中科院分区：
文献类型：
--
作者：
Dave,VP;Hetherington,SV;Portner,A;Leggiadro,RJ;Hurwitz,JL
根据抗原相似性，副流感病毒（PIV）分为4种不同类型（1- 4型）。本文描述了9例1型病毒感染患者的核蛋白（NP）序列变异性的评价。NP序列的短片段的检查足以定义患者样品内和之间的显著变异性。这些数据，结合先前对PIV感染患者人群的血凝素-神经氨酸酶和融合蛋白序列的研究，表明每种病毒类型的分离株之间缺乏绝对稳定性。潜在地，抗原变异性存在到针对一种分离株引起的免疫应答可能不能完全保护另一种相同类型的程度。因此，序列变异性可能导致PIV的自然再感染，以及先前的疫苗失败。结果强调了分析突破疫苗诱导免疫的病毒的重要性，以衡量病毒多样性对PIV疫苗结果的影响。
Parainfluenza viruses (PIV) have been categorized into four discrete types (types 1–;4), based on antigenic similarities. Here is described an evaluation of nucleoprotein (NP) sequence variability among nine patients infected with the type 1 virus. The examination of short segments of the NP sequence was sufficient to define significant variability both within and between patient samples. These data, in conjunction with previous studies of hemagglutinin-neuraminidase and fusion protein sequences from PIV-infected patient populations suggest a lack of absolute stability among isolates within each virus type. Potentially, antigenic variability exists to the extent that an immune response elicited toward one isolate may not be fully protective against another of the same type. Thus, sequence variability could contribute to natural re-infections with PIV, as well as to previous vaccine failures. Results highlight the importance of analyzing viruses that break through vaccine-induced immunity, in order to measure the influence of virus diversity on PIV vaccine outcome.