EFFECTS OF MAGAININS AND CECROPINS ON THE SPOROGONIC DEVELOPMENT OF MALARIA PARASITES IN MOSQUITOS
EFFECTS OF MAGAININS AND CECROPINS ON THE SPOROGONIC DEVELOPMENT OF MALARIA PARASITES IN MOSQUITOS
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DOI：
10.1128/iai.57.9.2628-2633.1989
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发表时间：
1989-09-01
影响因子：
3.1
通讯作者：
MILLER, LH
中科院分区：
文献类型：
--
作者：
GWADZ, RW;KASLOW, D;MILLER, LH
Magainins 和天蚕素是具有广泛抗菌和抗寄生虫活性的肽家族，分别源自青蛙皮肤或巨皮丝蛾。在昆虫中，天蚕素是诱导性免疫系统的一部分，可抵抗多种细菌感染。当注射到之前感染过多种疟原虫的按蚊体内时，magainin 和天蚕素都会通过中止卵囊的正常发育来破坏孢子发育。 子孢子不会形成，载体不能将寄生虫传播给另一个宿主。通过将编码margainins、天蚕素或类似作用的杀寄生虫肽的基因引入和表达到蚊子基因组中，可以在蚊子载体中诱导有效的传播阻断免疫。
Magainins and cecropins are families of peptides with broad antimicrobial and antiparasitic activities derived respectively from the skin of frogs or from gian skin silk moths. In insects, cecropins function as part of an inducible immune system against a number of bacterial infections. When injected into anopheline mosquitoes previously infected with a variety of Plasmodium species, both magainins and cecropins disrupt sporogonic development by aborting the normal development of oocysts; sporozoites are not formed and the vector cannot transmit the parasite to another host. It may be possible to induce effective transmission-blocking immunity in the mosquito vector by the introduction and expression of genes coding for margainins, cecropins, or similarly acting parasiticidal peptides into the mosquito genome.