Crosstalk between triple negative breast cancer and microenvironment.
Crosstalk between triple negative breast cancer and microenvironment.
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DOI：
10.18632/oncotarget.28397
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发表时间：
2023-03-31
期刊：
影响因子：
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通讯作者：
Jin, Kideok
中科院分区：
文献类型：
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作者：
Smrekar, Karly;Belyakov, Artem;Jin, Kideok
尽管在乳腺癌的治疗方面已经取得了许多进展，但对于三阴性乳腺癌（TNBC），这些疗法并没有显著提高总生存率。肿瘤微环境（TME）在TNBC的发生和控制中起着至关重要的作用。许多临床前和临床研究正在进行中，以治疗患有TNBC疾病的患者，但目前还没有有效的治疗方法。在这里，我们回顾了最近在了解TNBC方面的进展，以及在确定TNBC治疗机制和克服TNBC的潜在治疗策略方面的进展。
Although many advances have been made in the treatment of breast cancer, for the triple negative breast cancer (TNBC) these therapies have not significantly increased overall survival. Tumor microenvironment (TME) plays an essential role to develop and control TNBC progression. Many preclinical and clinical studies are ongoing to treat patients with TNBC disease, but the effective therapies are currently not available. Here, we have reviewed recent progress in understanding of TNBC and advance in defining mechanisms of TNBC therapies and potential therapeutic strategies to overcome TNBC.