Arterial spin labeling perfusion imaging demonstrates cerebral hyperperfusion in anti-NMDAR encephalitis.
Arterial spin labeling perfusion imaging demonstrates cerebral hyperperfusion in anti-NMDAR encephalitis.
复制标题
DOI：
10.1016/j.radcr.2017.06.004
复制
发表时间：
2017-12
影响因子：
--
通讯作者：
Burdette JH
中科院分区：
文献类型：
--
作者：
Sachs JR;Zapadka ME;Popli GS;Burdette JH
抗N-甲基-d-天冬氨酸受体脑炎是一种日益被认识到的自身免疫性疾病，其导致大量发病、延长住院时间，甚至死亡。由于缺乏或仅有细微的初始磁共振成像结果和非特异性临床综合征，诊断通常被延迟或完全无法识别。发现这种疾病的早期影像学表现可能有助于临床医生更积极地治疗这种自身免疫性脑炎，并可能降低发病率和死亡率。我们报告了一例抗N-甲基-d-天冬氨酸受体脑炎的新病例，其特征是动脉自旋标记灌注成像显示脑灌注增加的早期证据，这一发现早于实验室诊断和常规磁共振成像异常。需要进一步的研究来确定这一发现的病理基础。
Anti-N-methyl-d-aspartate receptor encephalitis is an increasingly recognized autoimmune disorder that results in substantial morbidity, prolonged hospital stays, and even death. The diagnosis is often delayed or unrecognized entirely as a result of absent or only subtle initial magnetic resonance imaging findings and a nonspecific clinical syndrome. The discovery of early imaging findings in this disease may help clinicians to more aggressively treat this autoimmune encephalitis and to potentially lessen morbidity and mortality. We report a novel case of anti-N-methyl-d-aspartate receptor encephalitis characterized by early evidence of increased cerebral perfusion on arterial spin labeling perfusion imaging, a finding that preceded laboratory diagnosis and conventional magnetic resonance imaging abnormalities. Further investigation is needed to firmly establish the pathologic basis of this finding.