Impaired off-line memory consolidation in depression
Impaired off-line memory consolidation in depression
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DOI：
10.1016/j.euroneuro.2010.02.002
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发表时间：
2010-08-01
影响因子：
5.6
通讯作者：
Steiger, Axel
中科院分区：
文献类型：
--
作者：
Dresler, Martin;Kluge, Michael;Steiger, Axel
睡眠与程序性记忆的巩固密切相关。在重度抑郁症（MD）和抗抑郁药物治疗期间，睡眠脑电图的变化有据可查。在这里，我们测试离线运动记忆巩固是否受损。对50例MD急性发作患者、50例正常对照组和12例MD缓解期患者进行了连续性手指叩击测试。虽然抑郁症患者和对照组在实践依赖性学习方面没有差异，但健康受试者的敲击表现在夜间明显改善了18%，而患者则没有任何改善。当受试者除以30岁的年龄阈值时，这种模式变得更加惊人：在30岁以上组中，健康受试者显示出运动表现的夜间增加16%，而患者显示出约10%的夜间下降。相比之下，患者和对照组中，
Sleep is critically involved in the consolidation of procedural memory. In major depression (MD) and during antidepressant pharmacotherapy, changes in sleep EEG are well documented. Here, we test if off-line motor memory consolidation is impaired in MD. 50 medicated patients with an acute episode of MD, 50 normal controls and 12 patients with a remitted episode of MD were assessed using a sequential finger tapping task before and after a night of sleep. Although depressed patients and control subjects did not differ in practice-dependent learning, healthy subjects showed markedly overnight improvements in tapping performance of 18% while patients failed to show any improvement. This pattern became even more striking when the subjects were divided by an age threshold of 30 years: In the 30+ yrs group the healthy subjects showed 16% overnight increase in motor performance, whereas the patients showed -10% overnight decrease. In contrast, patients and controls in the