CHANGES IN MUSCLE SYMPATHETIC-NERVE ACTIVITY DURING SLEEP IN HUMANS
CHANGES IN MUSCLE SYMPATHETIC-NERVE ACTIVITY DURING SLEEP IN HUMANS
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DOI：
10.1212/wnl.41.12.1961
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发表时间：
1991-12-01
期刊：
影响因子：
9.9
通讯作者：
WATANABE, T
中科院分区：
文献类型：
--
作者：
OKADA, H;IWASE, S;WATANABE, T
我们通过显微神经造影记录了 12 名健康志愿者睡眠期间的肌肉交感神经活动 (MSA)，同时记录了 EEG、EOG、ECG、呼吸和血压，并确定了非快速眼动 (nonREM) 睡眠和快速眼动 (REM) 睡眠的每分钟脉冲同步 MSA 爆发次数（爆发率）。随着睡眠阶段逐渐加深，MSA 在非快速眼动睡眠期间下降。在快速眼动睡眠期间，MSA 的爆发率增加，并与动脉血压的显着波动相关。在睡眠第 2 阶段，MSA 爆发发生在自发 K 复合波后约 1 秒。我们的结论是：（1）非快速眼动睡眠阶段 MSA 的减少可能表明 MSA 活动的睡眠阶段依赖性中枢抑制； (2) REM睡眠期间MSA增加提示自主神经系统不稳定； (3) MSA 爆发和 K 复合物可能存在共同途径。
We microneurographically recorded muscle sympathetic nerve activity (MSA) during sleep in 12 healthy volunteers while simultaneously recording EEG, EOG, ECG, respiration, and blood pressure and determined the number of pulse-synchronous MSA bursts per minute (burst rate) for non-rapid eye movement (nonREM) sleep and rapid eye movement (REM) sleep. MSA decreased during nonREM sleep with progressively deeper sleep stages. During REM sleep, the burst rate of MSA increased and was associated with marked fluctuations in arterial blood pressure. During sleep stage 2, MSA bursts occurred approximately 1 second after spontaneous K-complexes. We conclude that (1) the decreases in MSA during nonREM sleep stages may indicate sleep-stage dependent central suppression of MSA activity; (2) increases in MSA during REM sleep suggest instability of the autonomic nervous system; and (3) a common pathway may exist for MSA bursts and K-complexes.