[On the changes of plasmin activity caused by radiation treatment in cancer patients and effects of antiplasmin (Ipsilon) administration].
[On the changes of plasmin activity caused by radiation treatment in cancer patients and effects of antiplasmin (Ipsilon) administration].
复制标题
癌症患者放射治疗引起的纤溶酶活性变化及抗纤溶酶（Ipsilon）给药的影响[J].
DOI：
10.2302/kjm.10.195
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发表时间：
1961
期刊：
影响因子：
--
通讯作者：
T. Tanaka
中科院分区：
文献类型：
--
作者：
H. Yamashita;S. Igari;T. Tanaka
克朗凯特在1946年对暴露于比基尼爆炸的动物进行实验时发现，山羊和猪出现了出血素质，并观察到它们的纤维蛋白溶解酶显着增加。从那以后，又进行了许多其他的实验。Leeuw、Wright和他们的同事使用兔子，Colgan和Sanderson使用狗，Kocholaty、Ellis和他们的同事使用大鼠，并给予相当大剂量的全身照射，注意到循环血液中纤溶酶或纤溶酶的快速活化。特别是据报道，在出血导致死亡之前，纤溶酶迅速升高。Colgan进一步报道了照射后3-4天尿中纤溶酶的突然激活，此后活性开始减弱，但在死亡前立即伴随出血再次迅速增加。相反，Kocholaty和他的同事报道，抗纤溶酶在照射后2天开始下降，在第4天达到最低点，从那时起继续略有增加。作者之一Yamashita先前给予家兔相当大剂量（1000 r）的Co-60 γ射线全身照射，并注意到从第3天起血液中纤溶酶活性升高。Yamashita进一步研究了接受放射治疗的患者的纤溶酶活性，并注意到在1000-2000 r的局部照射后不久，血液和尿液中的纤溶酶活化。持续约3周后，激活消失。这个实验表明了某种程度的关系与放射病。本文对癌症病人在放射治疗过程中血、尿中纤溶酶活性的变化进行了详细的研究。同时研究了纤溶酶的变化与放射病的关系，特别是大量服用合成抗纤溶酶药物--这些研究获得的结果报告在以下各行中。
Cronkite found during his experiments on animals exposed to the blasts at Bikini in 1946 that haemorrhagic diathesis occurred in goats and pigs, and observed remarkable increase of fibrinolysin in them. Since then many other experiments were made. Leeuw, Wright and their co-workers using rabbits, Colgan and Sanderson using dogs, and Kocholaty, Ellis and their co-workers using rats, and giving rather large doses of total body irradiation noted rapid activation of plasmin or fibrinolysin in the circulating blood. In particular plasmin was reported to have highly increased immediately before death caused by bleeding. Colgan further reported sudden activation of plasmin in the urine 3-4 days after irradiation, after which the activity began to weaken but rapidly increased again immediately before death accompanying bleeding. Kocholaty and his co-workers on the contrary reported that antiplasmin began to decrease in 2 days after irradiation, reaching the lowest on the 4th day, and from then on showing continued slight increase. One of the authors, Yamashita, previously gave rabbits rather large doses (1000 r) of total body irradiation of Co-60 gamma rays, and noted from the 3rd day elevation of plasmin activity in the blood. Yamashita made further investigations on the activity of plasmin in patients treated with radiation and noticed the activation of plasmin in the blood and the urine soon after a localized irradiation of 1000-2000 r. The acti vation kept up for about 3 weeks and thereafter disappeared. This experiment suggested a certain degree of relationship with radiation sickness. We have taken up a detailed investigation of the change of the plasmin activity in the blood and in the urine of cancer patients during radiation therapy. At the same time we studied the relationship of the plasmin changes to the radiation sickness, especially by administrating large amounts of -aminocaproic acid Upsilon), a synthetic antiplasmin drug. The results obtained by these investigations are reported in the following lines.