Sphingosine kinase: biochemical and cellular regulation and role in disease.
Sphingosine kinase: biochemical and cellular regulation and role in disease.
复制标题
DOI：
10.5483/bmbrep.2006.39.2.113
复制
发表时间：
2006-03
期刊：
影响因子：
--
通讯作者：
Tarek A. Taha;Y. Hannun;L. Obeid
中科院分区：
文献类型：
--
作者：
Tarek A. Taha;Y. Hannun;L. Obeid
鞘脂已经作为其代谢受到调节的分子出现，导致产生生物活性产物，包括神经酰胺、鞘氨醇和鞘氨醇-1-磷酸。这些生物活性产物的细胞水平之间的平衡越来越被认为对细胞调节至关重要;由此，神经酰胺和鞘氨醇引起细胞凋亡和生长停滞表型，并且鞘氨醇-1-磷酸介导增殖和血管生成反应。鞘氨醇激酶是调节这些脂质水平的关键酶，并且正在成为一种重要的和受调节的酶。本文综述了鞘氨醇激酶的调节机制及其在疾病中的作用。
Sphingolipids have emerged as molecules whose metabolism is regulated leading to generation of bioactive products including ceramide, sphingosine, and sphingosine-1-phosphate. The balance between cellular levels of these bioactive products is increasingly recognized to be critical to cell regulation; whereby, ceramide and sphingosine cause apoptosis and growth arrest phenotypes, and sphingosine-1-phosphate mediates proliferative and angiogenic responses. Sphingosine kinase is a key enzyme in modulating the levels of these lipids and is emerging as an important and regulated enzyme. This review is geared at mechanisms of regulation of sphingosine kinase and the coming to light of its role in disease.