Corticospinal Tract Change in the Unaffected Hemisphere at the Early Stage of Intracerebral Hemorrhage: A Diffusion Tensor Tractography Study
Corticospinal Tract Change in the Unaffected Hemisphere at the Early Stage of Intracerebral Hemorrhage: A Diffusion Tensor Tractography Study
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DOI：
10.1159/000281108
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发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Jang, Sung Ho
中科院分区：
文献类型：
--
作者：
Kwak, So Young;Yeo, Sang Seok;Jang, Sung Ho
目的：未受影响的脑半球的贡献是卒中后运动恢复机制之一。我们试图研究脑出血（ICH）患者早期未受影响半球皮质脊髓束（CST）的变化，使用弥散张量束造影（DTT）。对象和方法：纳入53例连续偏瘫患者和40例年龄和性别匹配的对照组。在ICH早期（发病后7-28天）采用1.5特斯拉系统进行DTT。我们测量了未受影响半球的纤维数、分数各向异性和表观扩散系数，并评估了受影响肢体的运动功能。结果：患者组未受影响半球CST纤维数明显高于对照组（p = 0.000）。各向异性分数值低于对照组（p = 0.018）。两组间表观扩散系数值比较差异无统计学意义（p = 0.654）。结论：我们证明了在脑出血患者早期使用DTT时，未受影响半球的CST发生了改变。版权所有：S. Karger AG，巴塞尔
Objectives: Contribution by the unaffected hemisphere is one of the motor recovery mechanisms following stroke. We attempted to investigate changes in the corticospinal tract (CST) in the unaffected hemisphere at the early stage in patients with intracerebral hemorrhage (ICH), using diffusion tensor tractography (DTT). Subjects and Methods: Fifty-three consecutive hemiparetic patients and 40 age-and sex-matched control subjects were enrolled. DTT was performed using a 1.5-tesla system at the early stage of ICH (7-28 days after onset). We measured the fiber number, fractional anisotropy and apparent diffusion coefficient of CST tractography in the unaffected hemisphere, and assessed the motor function of the affected extremities. Results: The fiber number of the CST in the unaffected hemisphere of the patient group was higher than that of the control group (p = 0.000). In contrast, the fractional anisotropy value was lower than that of the control group (p = 0.018). However, there were no significant differences in the apparent diffusion coefficient values between the 2 groups (p = 0.654). Conclusions: We demonstrated that the CST in the unaffected hemisphere was changed at the early stage in patients with ICH, using DTT. Copyright (C) 2010 S. Karger AG, Basel